نتایج جستجو برای: rifampicin
تعداد نتایج: 5438 فیلتر نتایج به سال:
INTRODUCTION The efficacy of tuberculosis (TB) treatment in Human Immunodeficiency Syndrome (HIV) co-infected patients may be compromised by genetic and pharmacokinetic variation in drug disposition. Rifampicin is a critical component of TB treatment. We investigated the influence of drug transporter gene polymorphisms on rifampicin concentrations in TB-HIV co-infected patients in Durban, South...
OBJECTIVES Pharmacokinetic interactions between rifampicin and antiretroviral therapy (ART), including efavirenz, are problematic and need to be better defined to determine proper dose and to be correlated with short-term and long-term clinical outcomes. PATIENTS AND METHODS Consenting patients with smear-positive pulmonary TB and HIV received once daily didanosine + lamivudine + efavirenz (6...
The prognosis of patients with previously treated tuberculosis (TB) was suggested to be dependent on whether the initial treatment was in compliance with the established guidelines. The aim of this retrospective multicenter study was to determine the proportion of new TB patients who received standard doses of rifampicin in multiple provinces of China, and the relationship between low doses of ...
The drug-parasite relationships for isoniazid and rifampicin have been investigated, using cultures of M. tuberculosis and infected guinea-pigs. It is remarkable that there appear to be two entirely different mechanisms involved in intermittent chemotherapy with isoniazid and rifampicin. With isoniazid, any escape from the influence of the drug leads to diminished efficacy. On the other hand, w...
Khuhawar et al. (1998) studied the HPLC determination of rifampicin, isoniazid and pyrazinamide in the pharmaceutical preparations. Isoniazid alone and along with pyrazinamide and rifampicin has been estimated by HPLC. Rifampicin and pyrazinamide were separated from the derivative of isoniazid and are simultaneously determined. The chromatography is carried out from C18 column. These drugs were...
Seventy human immunodeficiency virus (HIV)-infected patients receiving rifampicin and 70 HIV-infected patients not receiving rifampicin were enrolled to receive 400 mg of nevirapine-based highly active antiretroviral therapy per day. Mean plasma nevirapine levels at 8 and 12 weeks were lower in patients receiving rifampicin (P=.048). However, virological and immunological outcomes at 24 weeks w...
TO THE EDITOR—Human immunodeficiency virus (HIV) and tuberculosis are closely intertwined, and the number of coinfected patients continues to grow rapidly [1]. Treating both infections can be a challenge owing to multiple drug interactions and risk of overlapping side effects [2]. The utilization of rifampicin as part of tuberculosis treatment limits the use of antiretroviral (ARV) drugs. Rifam...
Tolerance of Rifampicin SIR,-One of the virtues of rifampicin is said to be a good patient tolerance which, as you have noted (30 August, 1969, p. 487), should be particularly valuable in treatment of tuberculosis where tolerance is poor. To demonstrate objectively whether this good tolerance extends to domiciliary ambulant therapy we have used a simple urine test for rifampicin on patients att...
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