نتایج جستجو برای: rhd

تعداد نتایج: 1294  

Journal: :Blood 1990
C Bloy P Hermand B Cherif-Zahar H H Sonneborn J P Cartron

The RhD polypeptide and LW glycoprotein were separately immunopurified with monoclonal antibodies and compared by two-dimensional (2-D) iodopeptide mapping after digestion with alpha-chymotrypsin. These proteins have distinct 2-D maps, as seen after 125I-labeling tyrosine residues (chloramine-T procedure), and even more strikingly after labeling primary amine residues (Bolton-Hunter procedure)....

Journal: :American journal of clinical pathology 2010
Dehua Wang Catherine Lane Karen Quillen

RhD determination in pregnant women is critical to facilitate Rh immune globulin prophylaxis for RhD-negative women. A single amino acid change in the RhD antigen can cause epitope loss, giving rise to "partial D" variants. Women with some partial D variants may develop anti-D against the missing epitope after pregnancy. RBCs with partial D may type as D-positive or D-negative depending on the ...

Journal: :Blood 2002
Isabelle Mouro-Chanteloup Anne Marie D'Ambrosio Pierre Gane Caroline Le Van Kim Virginie Raynal Didier Dhermy Jean-Pierre Cartron Yves Colin

In most cases, the lack of Rh in Rh(null) red cells is associated with RHAG gene mutations. We explored the role of RhAG in the surface expression of Rh. Nonerythroid HEK293 cells, which lack Rh and RhAG, or erythroid K562 cells, which endogenously express RhAG but not Rh, were transfected with RhD and/or RhAG cDNAs using cytomegalovirus (CMV) promoter-based expression vectors. In HEK293 cells,...

2018
Nan Phyu Sin Toe Myint Ne Myo Aung Myint Soe Win Thu Ya Htut Anna P Ralph David A Cooper Myo Lwin Nyein Mar Mar Kyi Josh Hanson

BACKGROUND Rheumatic heart disease (RHD) is a major cause of premature death in low and middle-income countries. The greatest barrier to RHD control is neglect of the disease in national health policies and a lack of prevalence data that might inform control efforts. Myanmar is making remarkable progress against many infectious diseases, but there are almost no data to define the clinical burde...

2015
Samantha M Colquhoun John R Condon Andrew C Steer Shu Q Li Steven Guthridge Jonathan R Carapetis

BACKGROUND Recent estimates of the global burden of rheumatic heart disease (RHD) have highlighted the paucity of reliable RHD mortality data from populations most affected by RHD. METHODS AND RESULTS We investigated RHD mortality rates and trends for Indigenous and non-Indigenous Australians in the Northern Territory (NT) for the period 1977-2005 and seminationally (NT plus 4 other states, c...

2017
Maheshkumar Poomarimuthu Sivakumar Elango Sambath Soundrapandian Jayalakshmi Mariakuttikan

BACKGROUND Rheumatic heart disease (RHD) is an autoimmune disease where cross reactive CD4+ T cells are involved in the pathogenesis of valvular damage. Human Leukocyte Antigen-G (HLA-G), an immunosuppressive molecule playing a crucial role in the inhibition of T cell response is associated with the pathogenesis of various autoimmune and inflammatory diseases. Genetic polymorphisms within the 3...

2016
Hailu Abera

Objective: To determine the prevalence of rheumatic heart disease (RHD) among primary school students in Shashemene town of Oromia regional state of Ethiopia. Method: Using a cross sectional study design and a multistage sampling technique, pupils were selected from public and private primary schools in Shashemene town. They were clinically screened for evidence of RHD by auscultating for signi...

2017
Xiaochen Wu Qin Yue Weikun Jia Jinbao Zhang Hui Ouyang Dong Xin Yingbin Xiao

BACKGROUND & OBJECTIVES Acute rheumatic fever and rheumatic heart disease (RHD) are important public health problems in developing countries. In this study, peptidomic analyses on RHD patients and healthy individuals were performed to characterize variations in serum peptide levels using label-free quantitation approaches. METHODS Blood samples were obtained from 160 healthy controls and 160 ...

Journal: :Tropical medicine & international health : TM & IH 1998
D Porignon E M Soron'Gane T E Lokombe D K Isu P Hennart W Van Lerberghe

BACKGROUND Since the eighties, the North Kivu Province socio-economic environment has been deteriorating. This province also faced an influx of Rwandan refugees in July 1994. The objective of the paper is to show how a rural health district has been able to adjust and maintain its medical activities under unfavourable conditions. METHOD Performances of the local health system were assessed th...

2016
Xue Zhong Xiang-Jun Rao Hui-Yu Yi Xin-Yu Lin Xiao-Hong Huang Xiao-Qiang Yu

Nuclear factor κB (NF-κB) plays an essential role in regulation of innate immunity. In mammals, NF-κB factors can form homodimers and heterodimers to activate gene expression. In insects, three NF-κB factors, Dorsal, Dif and Relish, have been identified to activate antimicrobial peptide (AMP) gene expression. However, it is not clear whether Dorsal (or Dif) and Relish can form heterodimers. Her...

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