نتایج جستجو برای: rfp

تعداد نتایج: 1059  

Journal: :Anticancer research 2012
Kensuke Yamauchi Yasunori Tome Norio Yamamoto Katsuhiro Hayashi Hiroaki Kimura Hiroyuki Tsuchiya Katsuro Tomita Michael Bouvet Robert M Hoffman

Stromal cells are essential for tumor growth. Stromal cells interact with cancer cells during tumor growth and progression. We report here the development of a tri-color imageable mouse model to visualize the interaction between host cells and cancer cells. To observe subcellular cancer cell dynamics in vivo, HT-1080 human fibrosarcoma cells were labeled in the nucleus with histone H2B-green fl...

Journal: :Applied and environmental microbiology 2011
Anna Pollithy Tina Romer Claus Lang Frank D Müller Jonas Helma Heinrich Leonhardt Ulrich Rothbauer Dirk Schüler

Numerous applications of conventional and biogenic magnetic nanoparticles (MNPs), such as in diagnostics, immunomagnetic separations, and magnetic cell labeling, require the immobilization of antibodies. This is usually accomplished by chemical conjugation, which, however, has several disadvantages, such as poor efficiency and the need for coupling chemistry. Here, we describe a novel strategy ...

2016
Xiaofei Ren Wei Wang Yi Cai Jianming Xu Liyu Cao Wen Hu Xi Chen Yulin Song

Background: It is known that antituberculosis drugs initially induce liver injury, and then the liver progressively adapts to the drug and mitigates the drug-induced liver injury. This study aimed to explore the molecular mechanisms responsible for liver adaptation to Rifampicin (RFP). Methods: RFP was administered at a dose of 100 mg/kg·d to rats for 7 weeks. On days 0, 7, 14, 21, 28, 35, 42, ...

2016
Bo-Ram Lee Ho Kyung Ko Ju Hee Ryu Keum Young Ahn Young-Ho Lee Se Jin Oh Jin Hee Na Tae Woo Kim Youngro Byun Ick Chan Kwon Kwangmeyung Kim Jeewon Lee

Efficient delivery of tumor-specific antigens (TSAs) to lymph nodes (LNs) is essential to eliciting robust immune response for cancer immunotherapy but still remains unsolved. Herein, we evaluated the direct LN-targeting performance of four different protein nanoparticles with different size, shape, and origin [Escherichia coli DNA binding protein (DPS), Thermoplasma acidophilum proteasome (PTS...

Journal: :Cancer research 2003
Matthew H Katz Michael Bouvet Shinako Takimoto Daniel Spivack Abdool R Moossa Robert M Hoffman

In this study we demonstrate the ability of a novel, p.o.-administered cytosine analogue, CS-682, to effectively prolong survival and inhibit metastatic growth in an imageable orthotopic mouse model of pancreatic cancer. MIA-PaCa-2-RFP pancreatic cancer cells were transduced with the Discosoma red fluorescent protein (RFP) and orthotopically implanted onto the pancreas of nude mice. Tumor RFP f...

2015
Dieter Görtz Gerald S. Braun Yuichi Maruta Sonja Djudjaj Claudia R. van Roeyen Ina V. Martin Andrea Küster Hildegard Schmitz-Van de Leur Jürgen Scheller Tammo Ostendorf Jürgen Floege Gerhard Müller-Newen

Anti-cytokine therapies have substantially improved the treatment of inflammatory and autoimmune diseases. Cytokine-targeting drugs are usually biologics such as antibodies or other engineered proteins. Production of biologics, however, is complex and intricate and therefore expensive which might limit therapeutic application. To overcome this limitation we developed a strategy that involves th...

2016
Xiao-Bo Zhao Guo-Sheng Ren

BACKGROUND Diabetes mellitus is associated with an increased risk of breast cancer, but studies of the effects of diabetes on the prognosis of women with breast cancer have yielded inconsistent findings. The present meta-analysis aimed to investigate the impact of preexisting diabetes on the prognosis in terms of overall survival (OS), disease-free survival (DFS), and relapse-free period (RFP) ...

2008
J. R. Drake G. Rubinacci

Optimal feedback control of resistive-wall modes (RWM) is of common interest for toroidal fusion concepts that use conducting walls for stabilization of ideal MHD modes. From the RWM control point of view, the RFP situation is in many respects similar to the advanced tokamak situation in the presence of very low plasma rotation, where the most effective stabilizing mechanism is the feedback act...

2012
Yone J. Yoon Sheryl L. White Xianglian Ni Alexander P. Gokin Miguel Martin-Caraballo

AMPA receptors lacking the GluA2 subunit allow a significant influx of Ca(2+) ions. Although Ca(2+)-permeable AMPA receptors are a familiar feature at early stages of development, the functional significance of these receptors during the maturation of the nervous system remains to be established. Chicken lumbar motoneurons express Ca(2+)-permeable AMPA receptors at E6 but the Ca(2+) permeabilit...

2016
Kristin Boggs Nandakumar Venkatesan Ingmar Mederacke Yoshihiro Komatsu Steve Stice Robert F. Schwabe Charlotte M. Mistretta Yuji Mishina Hong-Xiang Liu Mirella Dottori

Taste buds, the sensory organs for taste, have been described as arising solely from the surrounding epithelium, which is in distinction from other sensory receptors that are known to originate from neural precursors, i.e., neural ectoderm that includes neural crest (NC). Our previous study suggested a potential contribution of NC derived cells to early immature fungiform taste buds in late emb...

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