The ability of platelets to adsorb vinblastine has been used to treat patients with immune thrombocytopenia. It is hypothesized that the drug-platelet complex is coated with antibody, taken up by macrophages which are then destroyed by the drug. We gave 16 courses of vinblastine-platelets to six patients with immune thrombocytopenia. Only one patient responded, and therefore we examined possibl...

The ensemble of forces that stabilize protein structure and facilitate biological function are intimately linked with the ubiquitous aqueous environment of living systems. As a consequence, biomolecular activity is highly sensitive to the interplay of solvent-protein interactions, and deviation from the native conditions, for example by exposure to increased thermal energy or severe dehydration...

A bimolecular chemical reaction in solution constitutes a many-body problem. Even in the pseudounimolecular limit, when one reactant ~say, B! is in large excess over the other ~say, A! there are many B molecules which compete over binding to A. Yet, such effects are generally thought to be of little practical relevance. This impression possibly stems from the intensive study of irreversible dif...

BACKGROUND Selective recognition and binding of IgG molecules is the basis for a host of immunological and affinity purification techniques. Capture of an IgG in these procedures relies chiefly on its interaction with one of a variety of reengineered bacterial receptors which bind to the Fc region of IgG molecules with very high affinity. While this interaction is extremely efficient in trappin...

Electron-deficient dinuclear rhodium complexes [Rh2Cl2(μ-dpmppp)(RNC)] (1), with the linear tetraphosphine ligand dpmppp, showed reversible binding of molecular oxygen to form asymmetric dirhodium η(2)-peroxo complexes [Rh2Cl2(O2)(μ-dpmppp)(RNC)] (2) stabilized by a Rh→Rh dative bond.

High molecular weight nonionic surfactants have been chemically modified to bind multivalent ions reversibly by using a moderate temperature stimulus as an on/off mechanism. Only above the critical micellization temperature (CMT) does binding of multivalent ions take place, whereas below the CMT, no binding occurs to the free surfactant molecules. Different calorimetric techniques have been use...

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Carbon dioxide is a gas that is changing our environment. Its role as a greenhouse gas is clear with the onset of global warming. In efforts to address this issue, ambitious and creative schemes are targeting materials including zeolites, silica gels, aluminas, and activated carbons, as well as sophisticated metal–organic frameworks (MOFs) for the benign capture and storage of carbon dioxide. A...

Diaminothiazoles are novel cytotoxic compounds that have shown efficacy toward different cancer cell lines. They show potent antimitotic and antiangiogenic activity upon binding to the colchicine-binding site of tubulin. However, the mechanism of action of diaminothiazoles at the molecular level is not known. Here, we show a reversible binding to tubulin with a fast conformational change that a...