نتایج جستجو برای: reverse transcriptase inhibitor

تعداد نتایج: 313286  

Journal: :The Journal of infectious diseases 2006
Rolando M Viani Ligia Peralta Grace Aldrovandi Bill G Kapogiannis Rick Mitchell Stephen A Spector Yolanda S Lie Jodi M Weidler Michael P Bates Nancy Liu Craig M Wilson

This study examined the prevalence of primary human immunodeficiency type 1 (HIV-1) drug resistance among recently infected youth in the United States. Of the 55 subjects studied, major mutations conferring HIV drug resistance were present in 10 (18%). Eight (15%) had nonnucleoside reverse-transcriptase inhibitor (NNRTI) mutations, with the majority (6) having the K103N mutation; 2 (4%) had nuc...

2015
Santiago Avila-Ríos Claudia García-Morales Daniela Tapia-Trejo Rita I. Meza Sandra M. Nuñez Leda Parham Norma A. Flores Diana Valladares Luisa M. Pineda Dixiana Flores Roxana Motiño Víctor Umanzor Candy Carbajal Wendy Murillo Ivette Lorenzana Elsa Y. Palou Gustavo Reyes-Terán Paul Richard Harrigan

INTRODUCTION We assessed HIV drug resistance (DR) in individuals failing ART (acquired DR, ADR) and in ART-naïve individuals (pre-ART DR, PDR) in Honduras, after 10 years of widespread availability of ART. METHODS 365 HIV-infected, ART-naïve, and 381 ART-experienced Honduran individuals were enrolled in 5 reference centres in Tegucigalpa, San Pedro Sula, La Ceiba, and Choluteca between April ...

2016
Santiago Avila-Rios Omar Sued Soo-Yon Rhee Robert W. Shafer Gustavo Reyes-Teran Giovanni Ravasi

BACKGROUND HIV transmitted drug resistance (TDR) remains at moderate level in Latin America and the Caribbean (LAC). However, different epidemiologic scenarios could influence national and sub-regional TDR levels and trends. METHODS AND FINDINGS We performed a systematic review of currently available publications on TDR in antiretroviral treatment-naïve adults in LAC. Ninety-eight studies pub...

2014
Frederic Crouzat Anita Benoit Colin Kovacs Graham Smith Nathan Taback Ina Sandler Jason Brunetta Benny Chang Barry Merkley David Tilley David Fletcher Dipen Kalaria Mona Loutfy

INTRODUCTION The resistance profiles of first-line antiretroviral therapy (ART) regimens after virologic failure have yet to be studied in a clinic setting in the modern treatment era. Time to virologic failure among three standard first-line regimens and the resistance profiles of these failures were compared. MATERIALS AND METHODS All HIV-positive persons aged 16 and over starting a three-d...

2012
Somnuek Sungkanuparph Chonlaphat Sukasem Sasisopin Kiertiburanakul Ekawat Pasomsub Wasun Chantratita

BACKGROUND After rapid scaling up of antiretroviral therapy in HIV-1-infected patients, the data of primary HIV-1 drug resistance in Thailand is still limited. This study aims to determine the prevalence and associated factors of primary HIV-1 drug resistance in Thailand. METHODS A prospective observational study was conducted among antiretroviral-naïve HIV-1-infected Thai patients from 2007 ...

2014
Marco Franzetti Michela Violin Andrea Antinori Andrea De Luca Francesca Ceccherini-Silberstein Nicola Gianotti Carlo Torti Stefano Bonora Maurizio Zazzi Claudia Balotta

BACKGROUND Despite a substantial reduction in virological failures following introduction of new potent antiretroviral therapies in the latest years, drug resistance remains a limitation for the control of HIV-1 infection. We evaluated trends and correlates of resistance in treatment failing patients in a comprehensive database over a time period of relevant changes in prescription attitudes an...

Journal: :AIDS research and human retroviruses 2005
Pachamuthu Balakrishnan Nagalingeswaran Kumarasamy Rami Kantor Suniti Solomon Sundararajan Vidya Kenneth H Mayer Michael Newstein Sadras P Thyagarajan David Katzenstein Bharat Ramratnam

Most studies of HIV-1 drug resistance have examined subtype B viruses; fewer data are available from developing countries, where non-B subtypes predominate. We determined the prevalence of mutations at protease and reverse transcriptase drug resistance positions in antiretroviral drug-naive individuals in southern India. The pol region of the genome was amplified from plasma HIV-1 RNA in 50 pat...

Journal: :hepatitis monthly 0
abrar hussain department of biotechnology and informtics, buitems, quetta, pakistan; national centre of excellence in molecular biology, university of the punjab, lahore, pakistan muhammad idrees national centre of excellence in molecular biology, university of the punjab, lahore, pakistan; national centre of excellence in molecular biology, university of the punjab, lahore, pakistan. tel: +92-3214769212 muhammad asif department of biotechnology and informtics, buitems, quetta, pakistan liaqat ali division of infectious diseases, department of internal medicine ii, university hospital freiburg, freiburg, germany; faculty of biology, albert ludwigs university of freiburg, freiburg, germany mahmood rasool center of excellence in genomic medicine research, (cegmr), king abdulaziz university, jeddah, saudi arabia

results phylogenetic analysis of the gene revealed that pakistani 1a hcv strains are in the start of third cluster and there is a difference between inter pakistani isolates at primary, secondary and tertiary levels. material and methods patient sera infected with hepatitis c virus, genotype 1a, were obtained from molecular diagnostics lab, cemb, university of the punjab lahore by using bd vacu...

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