The crude polar extract of mangosteen fruit pericarp not only has a moderate antioxidant activity (55±4 μg/mL) but also high cytotoxicity (16±0.5 μg/mL). presumably is caused by the presence complex cytotoxic compounds from pericarp. To obtain non-toxic preparation with activity, 50% ethanol extracts were partially purified using reverse-phase column chromatography Silica C18 as stationary phas...