A series of endotoxin injections, either in constant or progressively increasing increments, will induce a state of refractoriness termed endotoxin tolerance. Resistance to the febrile effect of endotoxin is believed to be of short duration, disappearing within 3 weeks (2). Inasmuch as bacterial endotoxins are potent 0 antigens and give rise to the production of specific antibody, early workers...

Salmonella typhimurium is a facultative intracellular pathogen capable of surviving within phagocytic cells of the reticuloendothelial system. To identify the genes important for intracellular survival, 9516 independent Tn10 insertional mutations were isolated in a virulent strain of S. typhimurium. By using an in vitro assay for survival within macrophages, 83 Tn10 mutants have been identified...

littoral cell angioma is a splenic vascular tumor of splenic sinus lining cells that is considered benign in general. this report describes a case of littoral cell angioma with no malignant histological features. the lesion is composed of anastomosing vascular channels resembling splenic sinus; they are lined by endothelial cells which show mitotic activity very rare. immunohistochemically, the...

Diffuse normolipemic plane xanthoma is characterized by thepresence of yellowish-orange plaques on the eyelids, neck, uppertrunk, buttocks and flexural surfaces of the extremities in patientswith a normal lipid profile. It mainly affects adults of both sexes.Diffuse normolipemic plane xanthomas are usually associatedwith reticuloendothelial system disorders, such a...

as evidence of autoimmune phenomena. The experimental production of positive antiglobulin tests by drugs and chemical agents, however, has suggested that nonimmunologic mechanisms may also be responsible for protein coating of erythrocytes.2’3 During attempts to produce tumors of the reticuloendothelial system in rats by injection of trypan blue, an anemia, chacacterized by increased ervthrocyt...