several scientists held the hope that the "Maltoni" work would clarify questions about MTBE's carcinogenic potential. Despite the enthusiasm of some scientists for Belpoggi's results, the most cursory examination of the paper reveals critical issues that show the data have been grossly overinterpreted. Rather than predicting a health hazard, the data indicate that rats tolerate enormous daily o...

a Drugs A and B have similar activity. a -l When the effective doses of A and B in combination are located in the area of m+n 1, m> 1, n> 1, they are called par tial antagonism. a -4 When they are located out of the square area, that is, m)1...

Exploitation of drug-drug synergism and allostery could yield superior therapies by capitalizing on the immensely diverse, but highly specific, potential associated with the biological macromolecular landscape. Here we describe a drug-drug synergy mediated by allosteric cross-talk in chromatin, whereby the binding of one drug alters the activity of the second. We found two unrelated drugs, RAPT...

CHEST, 78: 4, OCTOBER, 1980 Only eight cases diagnosed during life as a cyst of the thoracic duct have been reported.’3’59 Although Steinberg and Watson1#{176} reported some cases with a jugular lymph sac at the site of entrance of lymphatic channels into the vein, these cases were thought to be different from the other reported cases. Steinberg and Watson’#{176}concluded that a persistent embr...

Glucose is an essential fuel for cell survival and its availability limits aberrant cellular proliferation. We have hypothesized that specific cancer mutations regulate metabolic response(s) to glucose deprivation (GD). By means of somatic knock-in cellular models, we have analyzed the response to glucose deprivation in cells carrying the frequent (delE746-A750)EGFR, (G13D)KRAS or (E545K)PIK3CA...

The c-fos protooncogene is transcriptionally activated by a wide variety of agents including serum, growth factors, and phorbol esters. This induction is rapid and transient and is mediated through a number of identified promoter elements. Growth hormone (GH) is also known to induce transcription of c-fos in a variety of cell types including NIH 3T3 fibroblasts and 3T3-F442A preadipocytes. To i...

Synergism was demonstrated between Sendai virus and Pasteurella pneumotropica in the respiratory tract of mice showing no evidence of previous infection with either agent. Mice aerosol challenged with P. pneumotropica invariably eliminated the viable organism from their lungs within 72 h. In contrast, intrapulmonary killing was delayed in animals previously infected with Sendai virus. Maximum s...

The prevalence of excess body mass (XBM), poor oral health (POH), and stress in a secluded population of aged (≥60 years) Hmong immigrants was surveyed. The findings were related to the prevalence of diabetes in the same population. Diabetes was associated separately with POH (OR 2.4; CL 1.3, 4.2) or with XBM (OR 2.5; CL 1.4, 4.8). The association of diabetes with the combination of XBM and POH...