Congenital esophageal atresia with or without tracheoesophageal fistula (CEA ± TEF) is a relatively common malformation that occurs in 1 of 2500-4500 live births. Despite the refinement of surgical techniques, a considerable proportion of children experience short- and long-term respiratory complications, which can significantly affect their health through adulthood. This review focuses on the ...

The objective of this study was to assess the frequency of MBL2 genotypes and their associations with MBL levels and various morbidities of a neonatal intensive care unit (NICU). One hundred and thirty-four (134) NICU (83 term and 51 preterm) and 150 healthy neonates were enrolled in the study. MBL2 genotype and MBL serum levels at birth were determined prospectively by PCR-RFLP-sequencing and ...

AIM Preterm infants requiring surfactant replacement have been treated using the INSURE technique, which requires sedation and comprises tracheal intubation, surfactant instillation and extubation. However, minimally invasive surfactant therapy (MIST) does not require sedation, minimises airway injury and avoids placing positive pressure ventilation on an immature lung. This study compared the ...

OBJECTIVE To study the effectiveness and safety of non-invasive positive-pressure ventilation in the management of acute respiratory failure. DESIGN Prospective study. SETTING Regional public hospital, Hong Kong. PATIENTS One hundred and eighty-nine haemodynamically stable adult Chinese patients with acute respiratory failure (119 men and 70 women; mean age, 71.2 years [range, 18-92 years...

BACKGROUND Influenza virus predictably causes an annual epidemic resulting in a considerable burden of illness in Australia. Children are disproportionately affected and can experience severe illness and complications, which occasionally result in death. METHODS We conducted a retrospective descriptive study using data collated in the Australian and New Zealand Paediatric Intensive Care (ANZP...

BACKGROUND The traditional classification of COPD, which relies solely on spirometry, fails to account for the complexity and heterogeneity of the disease. Phenotyping is a method that attempts to derive a single or combination of disease attributes that are associated with clinically meaningful outcomes. Deriving phenotypes entails the use of cluster analyses, and helps individualize patient m...

Extreme prematurity is associated with an increased risk of mortality, morbidities and long-term neurodevelopmental impairment. Optimizing prenatal, perinatal and postnatal care is essential to improve long-term outcome of extremely preterm babies. Intrauterine growth restriction (IUGR) has been associated with a poorer neurological outcome and prenatal care should aim to an optimal balance bet...

OBJECTIVE To determine whether a limited oxygen strategy (LOX) versus a high oxygen strategy (HOX) during delivery room resuscitation decreases oxidative stress in preterm neonates. METHODS A randomized trial of neonates of 24 to 34 weeks' gestational age (GA) who received resuscitation was performed. LOX neonates received room air as the initial resuscitation gas, and fraction of inspired ox...

objectives we assessed the prevalence of three common viruses including; respiratory syncytial virus (rsv), human rhinovirus (hrv), and human metapneumovirus (hmpv), in children with acute wheezing. patients and methods ninety six wheezy children, 48 males (50%) and 48 females (50%)under the age of 5 years, were enrolled in the study. all patients visited as outpatients or inpatients when refer...