The first pandemic of the coronavirus family was caused by severe acute respiratory syndrome coronavirus 2 (SARSCoV-2) in late 2019. As a result of the pandemic critical condition, specialized orthopedic services were obviouslyaffected. To respond properly, we initiated a series of strategic measures, aiming at the safety of staff, minimizing theexposure, and prevention of pos...

infectious bronchitis (ib) is a very contagious disease caused by a coronavirus (ibv). in chickens, thevirus affects the respiratory, reproductive, and urinary systems. this study was carried out to determine theseroprevalence of anti-ibv antibodies in domestic village chickens. serum samples of 300 domestic villagechickens from esfahan (centeral iran) were collected and examined for the presen...

BACKGROUND As the threat of zoonoses and the emergence of pandemic-prone respiratory viruses increases, there is a need to establish baseline information on the incidence of endemic pathogens in countries worldwide. OBJECTIVES To investigate the presence of viruses associated with influenza-like illnesses (ILI) in Uganda. METHODS A cross-sectional study was conducted in which nasopharyngeal...

Coronaviruses are important pathogens that cause acute respiratory diseases in humans. Replication of the approximately 30-kb positive-strand RNA genome of coronaviruses and discontinuous synthesis of an extensive set of subgenome-length RNAs (transcription) are mediated by the replicase-transcriptase, a barely characterized protein complex that comprises several cellular proteins and up to 16 ...

Many coronaviruses are capable of interspecies transmission. Some of them have caused worldwide panic as emerging human pathogens in recent years, e.g., severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). In order to assess their threat to humans, we explored to infer the potential hosts of coronaviruses using a dual-model approa...

Middle East respiratory syndrome coronavirus (MERS-CoV) is an existential threat to global public health. The virus has been repeatedly detected in dromedary camels (Camelus dromedarius). Adult animals in many countries in the Middle East as well as in North and East Africa showed high (>90%) seroprevalence to the virus. Middle East respiratory syndrome coronavirus isolated from dromedaries is ...

The current threat of avian influenza to the human population, the potential for the reemergence of severe acute respiratory syndrome (SARS)-associated coronavirus, and the identification of multiple novel respiratory viruses underline the necessity for the development of therapeutic and preventive strategies to combat viral infection. Vaccine development is a key component in the prevention of...

UNLABELLED Mouse hepatitis virus (MHV) isolates JHM.WU and JHM.SD promote severe central nervous system disease. However, while JHM.WU replicates robustly and induces hepatitis, JHM.SD fails to replicate or induce pathology in the liver. These two JHM variants encode homologous proteins with few polymorphisms, and little is known about which viral proteins(s) is responsible for the liver tropis...

The 1974 article by my colleagues and me describing studies of coronavirus infection in hospitalized infants with acute lower respiratory–tract disease (LRTD) [1] takes on a particular interest in light of the 2002–2003 epidemic of severe acute respiratory syndrome (SARS) coronavirus infections, with the wider perspective provided by that event on emerging epidemics, acute respiratory infection...