BackgroundResistin is reported as an antagonistic hormone of insulin and in the literature. Nowadays, importance of resistin is being more highlighted in the metabolism of mother and fetus during pregnancy. This study aimed to assess the level of resistin in the umbilical cord and blood sugar at birth and evaluate the association of resistin and neonatal birth weight.Materials and MethodsThis c...

Introduction: It is widely accepted that low grade systemic inflammation plays a key role in obesity and related diseases and metabolic syndrome. The objective of this work was to evaluate the effect of aerobic training intervention on CRP and IL-10 in adult obese females. Methods: Thirty adult obese women (30≤BMI≤36) aged 30 to 40 years were randomly assigned to exercise (3 months aerob...

polycystic ovary syndrome (pcos) is a common endocrine / metabolic disorder in women of reproductive age .abdominal adiposity and obesity are frequently present in pcos. it now appears that, obesity is associated with a low-grade inflammation of white adipose tissue. adipokines play a significant role in the pathogenesis of a low-grade inflammation associated with obesity. among variety of adip...

conclusions based on these data, we can argue that circulating glucose concentration is not directly affected by serum resistin in t2dm. it seems that resistin affects glucose indirectly, through insulin resistance. results we found that serum resistin had a positive significant correlation with insulin resistance (p = 0.000, r = 0.64). no significant correlation was found between serum resisti...

OBJECTIVE The link between plasma resistin and obesity-related cardiometabolic disorders in children remains debatable. This study assessed the relationships of plasma resistin with cardiovascular risk factors, pro-inflammatory markers and insulin resistance index (HOMA-IR) in obese (Ob) adolescents and obese adolescents with metabolic syndrome (Ob-MS) compared to healthy controls (CO). METHO...

Resistin is secreted from adipocytes, and high circulating levels have been associated with obesity and insulin resistance. To investigate whether resistin could exert autocrine effects in adipocytes, we expressed resistin gene in 3T3-L1 fibroblasts using a lentiviral vector, and selected several stably-transduced cell lines under blasticidin selection. We observed that 3T3-L1 adipocytes expres...

Approximately 5-10% of subjects with pre-diabetes eventually progress to diabetes every year. While inflammation is thought to be involved in the development of obesity-related type 2 diabetes mellitus (T2DM), the relation between inflammation and pre-diabetes remains largely unexplored. In this study we examined a comprehensive panel of 10 serum biomarkers involved in overweight and obese subj...

Introduction Treatment resistant schizophrenia (TRS) affects at least 15-20% of newly diagnosed patients with schizophrenia. Clozapine treatment for this sub-group should be considered immediately after the failure in response to two antipsychotics (usually risperidone and olanzapine) received adequate doses time. Immune changes have been reported first episode psychosis, although results from ...

BACKGROUND Obesity hypoventilation syndrome (OHS) is associated with increased cardiovascular morbidity. What moderate chronic hypoventilation adds to obesity on systemic inflammation and endothelial dysfunction remains unknown. QUESTION To compare inflammatory status and endothelial function in OHS versus eucapnic obese patients. METHODOLOGY 14 OHS and 39 eucapnic obese patients matched fo...