نتایج جستجو برای: resistance to i 131 therapy

تعداد نتایج: 11251683  

2015
Keri A Streby Nilay Shah Mark A Ranalli Anne Kunkler Timothy P Cripe

Neuroblastoma is unique amongst common pediatric cancers for its expression of the norepinephrine transporter (NET), enabling tumor-selective imaging and therapy with radioactive analogues of norepinephrine. The majority of neuroblastoma tumors are avid for (123)I-metaiodobenzaguanidine (mIBG) on imaging, yet the therapeutic response to (131) I-mIBG is only 30% in clinical trials, and off-targe...

2011
Margareta Dobrenic Drazen Huic Marijan Zuvic Darko Grosev Ratimir Petrovic Tatjana Samardzic

BACKGROUND Low iodine diet (LID) is recommended in patients with differentiated thyroid cancer before radioiodine administration. Patients with increased thyroglobulin (Tg) level, but negative (131)I whole body scan present diagnostic and therapeutic dilemma. This study was designed to evaluate the benefit of a two-week LID in patients with elevated serum Tg levels and negative (131)I whole bod...

2014
Evgenia Ostroumova Alexander Rozhko Maureen Hatch Kyoji Furukawa Olga Polyanskaya Robert J. McConnell Eldar Nadyrov Sergey Petrenko George Romanov Vasilina Yauseyenka Vladimir Drozdovitch Viktor Minenko Alexander Prokopovich Irina Savasteeva Lydia B. Zablotska Kiyohiko Mabuchi Alina V. Brenner

Esmaeil Gharepapagh Mohsen Saghari

In research institute for nuclear medicine (Tehran University of Medical Sciences) 50 patients with follicular thyroid carcinoma were evaluted retrospectively. The purpose of the study was assesment of the response of iodine-131 therapy. The best result were achieved when the patient treated with iodine-131 for the first time, in the 4th decade of life, with total thyroidectomy and no met...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2004
Willy-Anne Nieuwlaat Ad R Hermus H Alec Ross Wilhelmina C Buijs Michela A Edelbroek Jo W Bus Frans H Corstens Dyde A Huysmans

UNLABELLED A single, low dose of recombinant human thyroid-stimulating hormone (rhTSH) doubles 24-h RAIU and causes a more homogeneous distribution of radioiodine on thyroid scintigrams of patients with nodular goiter. Pretreatment with rhTSH allows the therapeutic dose of (131)I to be reduced by 50%-60% without compromising the result of thyroid volume reduction. The present study focused on t...

Journal: :Journal of surgical oncology 2005
Derek T Woodrum Paul G Gauger

(131)I is an integral component in postsurgical management of well-differentiated thyroid cancer (WDTC), which includes papillary and follicular types. (131)I is used postsurgically to either destroy remaining thyroid tissue (thyroid ablation) or to treat recurrence and metastases (radioiodine therapy). (131)I is no longer a routine diagnostic modality, but it is widely used for remnant ablatio...

Journal: :Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004
Steven G DuBois Julia Messina John M Maris John Huberty David V Glidden Janet Veatch Martin Charron Randall Hawkins Katherine K Matthay

PURPOSE Iodine-131-metaiodobenzylguanidine ((131)I-MIBG) has been shown to be active against refractory neuroblastoma. The primary toxicity of (131)I-MIBG is myelosuppression, which might necessitate autologous hematopoietic stem-cell transplantation (AHSCT). The goal of this study was to determine risk factors for myelosuppression and the need for AHSCT after (131)I-MIBG treatment. PATIENTS ...

Journal: :Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2003
Akheel A Syed Carol Evans Marian Ludgate John H Lazarus

OBJECTIVE The aim of this study was to determine whether or not the titre of thyroid-stimulating hormone receptor antibody with stimulating (TRAb-S) activity changes in patients with Graves' disease (GD) or toxic multinodular goitres (TMNG) 3 months after treatment with sodium iodide ((131)I). SUBJECTS AND METHODS Serum specimens were obtained from 21 hyperthyroid patients (15 with GD and 6 w...

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