Background: Toxoplasma gondii is a protozoan parasite that infects up to a third of the world’s population. Toxoplasmosis is one of the classical conditions known to have a profound adverse effect on human reproductive functions, but a few investigations on male reproductive parameters were done. The aim of this investigation is Study on the effects of Toxoplasma gondii on reproductive paramete...

Livestock are an integral part of agriculture that contribute to 35 49% the agricultural GDP, 37 87% household incomes, and 15 17% foreign exchange earnings country. There about 33.02 million heads sheep 38.96 goats’ population in Ethiopia. They important components livestock subsector sources cash income, milk, meat, wool, manure, saving or risk mitigation during crop failures, property securi...

Acetamiprid (ACP) belonging to the neonicotinoid family used against wide array of pests in agriculture and domestic purposes. In this study, we evaluated the attenuating effects of ethanolic extract of Mangifera indica leaves (EEMI) in averting reproductive toxicity caused by ACP in male guinea pigs. Thirty male guinea pigs were randomly assigned to five treatment groups (n = 6). Grou...

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Nutrition can generate oxidative stress and trigger a cascade of molecular events that can disrupt oxidative and hormonal balance. Nutrient ingestion promotes a major inflammatory and oxidative response at the cellular level in the postprandial state, altering the metabolic state of tissues. A domino of unfavorable metabolic changes is orchestrated in the main metabolic organs, including adipos...

The Poly(ADP-ribose) polymerase-1 (PARP1) is a multifunctional nuclear protein involved in a variety of cellular functions. Recently, its role in the onset, progression and therapy resistance of cancers in general and reproductive cancers in particular has been recognised. The PARP associated signaling is perceived to play a key role in the development, sustenance and relapse of reproductive ca...

Bisphenol-A (BPA) is widely used in the plastic industry, and it is one of the well-studied endocrine disrupting chemicals (EDCs). Growing evidence raised the concern of BPA having weak estrogenic activity on human health including female reproductive functions and diseases. Serum BPA level is also associated with pregnancy loss, reproductive tract diseases and infertility. In fact, several cou...

Cysteine‑rich angiogenic inducer 61 (CCN1/Cyr61) is a prompt response transcription product activated by growth factors. As a member of the CCN family, it mediates cell survival, proliferation, differentiation, migration, adhesion and synthesis of the extracellular matrix by binding directly to the integrins and heparin sulfate proteoglycans or activating multiple signaling transduction pathway...

The metalloproteinase-like, disintegrin-like, cysteine-rich (MDC) family is a large group of sequence-related proteins, first characterized in the male reproductive tract, but subsequently also identified in non-reproductive tissues. Their primary translation products are of approximately 90 kDa and each can be divided into distinct domains which show remarkable homology to reprolysins; snake v...

Male-female interaction is important for finding a suitable mating partner and for ensuring reproductive success. Male sexual signals such as pheromones transmit information and social and sexual status to females, and exert powerful effects on the mate preference and reproductive biology of females. Likewise, male vocalizations are attractive to females and enhance reproductive function in man...