Plasma renin activity was estimated in 11 infants with severe congestive heart failure. The infants had congenital heart disease with left to right shunts and were receiving diuretic treatment. Plasma renin activity was measured by radioimmunoassay of generated concentrations of angiotensin I. The mean (SD) plasma renin activity was 84 (21) ng angiotensin I/ml/hour, which is considerably above ...

To investigate mechanisms involved in the high incidence of hypertension in diabetes mellitus, the relationship between renin-angiotensin production and renal prostaglandin E2 synthesis was studied in rats 1 week after diabetes mellitus had been induced by streptozotocin injection. The diabetic rats became hypertensive, although plasma renin activity did not increase despite the plasma volume c...

RAILIE, MICHAEL D., LARRY E. DAVIS, AND RODGER LOUTZENI-USER. Intrarenal secretion of renin in the dog: effect of furosemide. Am. J. Physiol. 224(2) : 425-430. 1973.-The activity of the renin was measured in systemic arterial plasma and renal hilar lymph following volume expansion with isotonic saline and after the intravenous administration of furosemide in volume-expanded dogs. lienin activit...

Supervisory Committee Dr. Christoph Borchers, Department of Biochemistry and Microbiology Supervisor Dr. Terry Pearson, Department of Biochemistry and Microbiology Departmental Member Dr. Patrick von Aderkas, Department of Biology Outside Member The renin-angiotensin-aldosterone system (RAAS) plays an essential role in maintaining plasma volume and arterial blood pressure by regulating angioten...

Background: The renin is a key performer in the renin–angiotensin system, and it offers a resource for the beneficial action of hypertension and heart malfunction. The keto piperazine based renin inhibitors have shown greater potential and good biavaibility. Objective: To develop a highly efficient QSAR model for 80 piperazines and keto piperazines to predict renin enzyme inhibitory activity. M...

ROBERTSON: We have this morning rather a large Round Table, with ten speakers, all of whom have been promised that they will get at least one chance to speak. Also quite a number of people in the audience have indicated to me that they wish to join in. Unfortunately, we are limited to 1 h. It is my job as Chairman to try to reconcile some of these obviously irreconcilable objectives and we shal...

Although it has been known for many years that the renin-angiotensin system is responsive to decreases in renal perfusion pressure (1-3), it was only recently discovered that angiotensin is an important regulator of aldosterone secretion (4-6). Before it was known that angiotensin had a role in the regulation of aldosterone secretion, a large number of studies indicated that experimental or pat...

The role of cyclooxygenase 2 (COX-2) in the control of renin is still a matter of debate, since studies with COX-2-deficient mice or with COX-2 inhibitors produced conflicting findings. Therefore, we studied the effect of the COX-2 inhibitor SC-58236 on the regulation of the renin system in adult rat kidneys. Renocortical tissue levels and urinary excretion of PGE(2) were reduced to 65 and 40% ...

Angiotensinogen, angiotensin-converting enzyme, and renin constitute the components of the renin-angiotensin system. The mammalian renal proximal tubule contains angiotensinogen, angiotensin-converting enzyme, and angiotensin receptors. Previous immunohistochemical studies describing the presence of renin in the proximal tubule could not distinguish synthesized renin from renin trapped from the...