Extended release formulation of alfuzosin, an a-antagonist used for prostatic hypertrophy, is available in market. It is convenient for older patients to take only one tablet a day. Marketed alfuzosin formulation is three layered geomatrix tablet that requires special facilities, high cost, more time and complex operation than normal direct compression formulation. Therefore, a less compl...

Objective(s): Pharmaceutical industries are leading to improved medications that can target diseases more effectively and precisely. Researchers have intended to reformulate drugs so that they may be more safely used in human body. The more targeted a drug is, the lower its chance of triggering drug resistance, a cautionary concern surrounding the use of broad-spectrum antibiotics. The aim of t...

The dual fuel engines at part loads inevitably suffer from lower thermal efficiency and higher carbon monoxide and unburned fuel emission. This work is carried out to investigate combustion characteristics of a dual fuel (dieselgas) engine at part loads, using a single zone combustion model with detailed chemical kinetics for combustion of natural gas fuel. The authors developed software in ...

in this study, the effects of various hydrophilic (hpmc and carbopol 971) and plastic (ethylcellulose and eudragit rl100) polymers on the release profile of diltiazem hcl from matrix tablets were evaluated in-vitro. for this purpose, tablets containing 60 mg of diltiazem hcl along with various amounts of the aforementioned polymers were prepared using the wet granulation technique. tablets prep...

Objective: The study is centered on formulation and evaluation of low viscosity metronidazole gel with varying amount Carbopol. Methods: Formulations (F1, F2 F3) Metronidazole in form were done amounts Prepared gels inspected for surface pH, viscosity, spreadability, antimicrobial susceptibility, drug content percentage, vitro process release, release kinetics stability testing. Findings: Formu...

X. Xu, M. Al-Ghabeish, Y. S. Krishnaiah, Z. Rahman, M. A. Khan U.S. Food and Drug Administration Purpose From a drug product quality perspective, in vitro release testing (IVRT) serves many different, yet crucial roles throughout the lifecycle of a drug product. Unfortunately, the maturity of IVRT methods for pharmaceutical ointments is considerably lacking and under-utilized as compared to con...

The rate of nonexchangeable NH/ release from soils can have a significant effect on N dynamics and environmental quality. Nonexchangeable NH/ is that N fraction which is fixed in the interlayers of clay minerals. The objective of this study was to determine the kinetics of nonexchangeable NH4 release from two topsoils from Germany [Giessen Ap (Aqualf) and Hungen Ap (Alfisol)] and from two subso...

The objectives of this study were (a) To Perform in-vitro release study of marketed Nifedipine formulation,(b) To check effect of integrity on release profiles, (c) To determine the possibility of switchover from one formulation to another formulation and (d) To compare release profiles with formulated batches by application of mathematical models. Four marketed and two prepared controlled rele...

Synapsins are a family of neuron-specific phosphoproteins that regulate neurotransmitter release by associating with synaptic vesicles. Synapsins consist of a series of conserved and variable structural domains of unknown function. We performed a systematic structure-function analysis of the various domains of synapsin by assessing the actions of synapsin fragments on neurotransmitter release, ...