Objective(s): Over the past two decades, considerable interest has been focused on utilizing biocompatible magnetic nanoparticles (MNPs) for biomedical applications. In this study, production of human serum albumin (HSA) nanoparticles using desolvation technique that were simultaneous loaded with high amounts of superparamagnetic iron oxide nanoparticles (SPIONs) and 5-flourouracil (5-FU) was i...

conclusions algino-pectinate mucoadhesive formulations exhibited promising properties of a sustained release form for piroxicam and provided distinct tissue protection in stomach. objective the purpose of this research was to decrease gastric side effects of piroxicam by formulating microspheres of alginate and algino-pectinate beads of the drug. materials and methods ionotropic gelation was us...

abstract due to calcareous soil conditions, zinc deficiency is a yield limiting factor for wheat production in iran. one solution for this problem is the cultivation of zn-efficient wheat varieties. ten wheat cultivars (nine bread wheat and one durum wheat) with different tolerance to zn deficiency were studied in a greenhouse experiment. plants were treated with zn (10 mg zn kg-1 soil as znso4...

objective(s) theophylline, a xanthenes derivative, is still widely used as an effective bronchodilator in the management of asthmatic patients. it is used both as a prophylactic drug and to prevent acute exacerbations of asthma. the aim of study was to formulate and evaluate effect of the microencapsulation of theophylline loaded nanoparticles on the reduction of burst release. materials and me...

The efficacy of a drug in a specific application requires the maintenance of appropriate drug blood level concentration during a prolonged period of time. Controlled release delivery is available for many routes of administration and offers many advantages (as microparticles and nanoparticles) over immediate release delivery. These advantages include reduced dosing frequency, better therapeutic...

Previous experience and research indicated that the Pareto Principle (80/20 Principle) has been widely used in many industries to achieve more with less. The study described in this paper concurs that this principle can be applied to improve the estimating accuracy and efficiency, especially in design development stage of projects. In fact, establishing an effective cost estimating model to imp...

Background: Progress in the field of biology and biochemistry has led to the discovery of numerous bioactive peptides and proteins in the last few decades. Delivery of therapeutic proteins/peptides has received a considerable amount of attention in recent years. Methods: In this study, a two-step desolvation method was used to produce biodegradable hydrophilic gelatin nanoparticles (GNP) as a d...

mesoporous silica nanoparticles with unique structure (sba-15) were synthesized and modified by [3-(2-aminoethylamino) propyl] trimethoxysilane (aeaptms). the synthesized nanoparticles were characterized by tga, n­2­ adsorption, sem, ftir, chn elemental analysis. the total weight loss for the modified sba-15 is 15.2% and thermal analysis revealed that 1.5 mmol aeaptms/1g sba-15 had been grafted...