The detection of fluctuating electromagnetic fields through single-spin relaxometry affords important insight into the dynamics solid-state systems and chemical processes, but its sensitivity is often limited by proximity sensor spin to target. This study proposes use an auxiliary reporter improve as much a factor 100, experimentally verifies method with single shallow nitrogen-vacancy center i...

PURPOSE The longitudinal relaxation rate (R1 ) measured in vivo depends on the local microstructural properties of the tissue, such as macromolecular, iron, and water content. Here, we use whole brain multiparametric in vivo data and a general linear relaxometry model to describe the dependence of R1 on these components. We explore a) the validity of having a single fixed set of model coefficie...

Introduction: T1-weighted imaging of the knees of adolescent girls with anorexia nervosa (AN) has been found to show consistently higher signal intensity and greater homogeneity in the femur and tibia as compared to normal adolescents, who typically exhibit striations and regions of lower signal, representing hematopoietic marrow. We performed T1 relaxometry measurements on a cohort of adolesce...

Nuclear magnetic resonance (NMR) relaxometry and diffusometry are important tools for the characterization of heterogeneous materials and porous media, with applications including medical imaging, food characterization and oil-well logging. These methods can be extremely effective in applications where high-resolution NMR is either unnecessary, impractical, or both, as is the case in the emergi...

Introduction: Recent development of methods to measure p0, in the clinic has generated data confirming a prognostic relationship between tumor p0, and clinical outcome. These results provide a powerful stimulus for development of enhanced methods for monitoring tumor ~0,. We have been developing a methodFRBDOM (Fluorine Relaxometry using Echo planar imaging for Dynamic Oxygen Mapping), which ty...

Rivastigmine has been shown to improve cognition in HIV+ patients with minor neurocognitive disorders; however, the mechanisms underlying such beneficial effect are currently unknown. To assess whether rivastigmine therapy is associated with decreased brain inflammation and damage, we performed T1/T2* relaxometry and magnetization transfer imaging in 17 aviremic HIV+ patients with minor neuroco...

Background: Iron accumulation in organs such as heart and liver can cause morbidity and mortality in transfusion-dependent patients with β-thalassemia major. MRI T2* relaxometry has been increasingly used in clinical practice for quantitative assessment of iron overload in heart and liver. For a heavily iron loaded liver, T2* is ultra-short (<1ms). In this scenario, conventional gradient echo s...

Magnetic nanoparticles have been widely used in the field of biotechnology and medicine, which has a great importance to precise and quantitative detection. This paper introduces a magnetic nanoparticles detection device of low cost, high sensitivity and real-time. When the diameter of the magnetic nanoparticles is 20nm, the third harmonic intensity of the induced voltage is in the level of mic...

Background Fibrosis is thought to play an important role in the pathogenesis of the adverse sequelae of hypertrophic cardiomyopathy (HCM). Late gadolinium enhancement (LGE) cardiovascular magnetic resonance detects replacement fibrosis but cannot presently detect interstitial fibrosis. The latter is thought to be a very early feature of HCM and can be triggered by inflammation, which can also e...

Most malaria deaths could be prevented if the infection is detected early. Thus, it is important to have access to a fast, sensitive, and reliable detection tool for the diagnosis of malaria in the clinical settings. However, the current malaria diagnosis relies on microscopic examination of blood smear, which is time consuming and labor intensive. Here, we present a novel malaria diagnosis tec...