To inform the UK antimicrobial resistance strategy, a risk assessment was undertaken of the likelihood, over a five-year time-frame, of the emergence and widespread dissemination of pan-drug-resistant (PDR) Gram-negative bacteria that would pose a major public health threat by compromising effective healthcare delivery. Subsequent impact over five- and 20-year time-frames was assessed in terms ...

BACKGROUND Exercise therapy encompasses a heterogeneous group of interventions. There continues to be uncertainty about the most effective exercise approach in chronic low back pain. PURPOSE To identify particular exercise intervention characteristics that decrease pain and improve function in adults with nonspecific chronic low back pain. DATA SOURCES MEDLINE, EMBASE, PsychInfo, CINAHL, an...

Marianne Trudel's contribution for the COVID-19 Special Issue. 
 Contribution de Trudel pour le numéro spécial COVID-19.

Cardio-respiratory instability (CRI) occurs frequently in acutely ill. If not identified and treated early, it leads to significant morbidity and mortality. Current practice primarily relies on vigilance of the clinical personnel for early recognition of CRI. Given limited monitoring resources available in critical care environment, it can be suboptimal. Thus, an "Early Warning Scoring" mechani...

Fig. 1. (a) Estimates of SVR12 achievement, medians with 95% CrIs, calculated by the Bayesian model. The numerical values of these estimates are as follows: SOF/LED-12 weeks, 93.17 (95% CrI: 98.35–99.76); SOF/LED-8 weeks, 77.84 (95% CrI: 93.64–98.71); SOF/DAC, 87.62 (95% CrI: 99.56–100); ARIOD, 83.42 (95% CrI: 93.88–97.93); and ARIODR, 93.15 (95% CrI: 97.27–99.12). (b) Histograms of rankings es...

Background Rigorous estimates for clearance rates of untreated chlamydia infections are important for understanding chlamydia epidemiology and designing control interventions, but were previously only available for women. Methods We used data from published studies of chlamydia-infected men who were retested at a later date without having received treatment. Our analysis allowed new infection...

BACKGROUND It is still debated whether there are differences among the various antihypertensive strategies in heart failure prevention. We performed a network meta-analysis of recent trials in hypertension aimed at investigating this issue. METHODS Randomized, controlled trials published from 1997 through 2009 in peer-reviewed journals indexed in the PubMed and EMBASE databases were selected....

BACKGROUND We aimed to identify different stroke prevention treatments for atrial fibrillation assessed in randomized controlled trials and to compare them within a single evidence synthesis framework. METHODS We updated the Cochrane review on anticoagulants and antiplatelet therapy for nonrheumatic atrial fibrillation to include randomized controlled trials published between January 2000 and...

The primary response of A/J mice to p-azobenzenearsonate-keyhole limpet hemocyanin (ABA-KLH) was investigated. A day-by-day analysis at the plaque- forming cell (PFC) level was performed, with inhibition by anti-cross- reactive idiotype (CRI) serum to determine percentage of CRI(+) PFC. A regular pattern in the dynamics of Id (idiotype) dominance was observed. Just as in the NP-b and NP-a syste...