objective(s): abnormal lung cell death including autophagy and apoptosis is the central feature in acute lung injury (ali). to identify the cellular mechanisms and the chronology by which different types of lung cell death are activated during lipopolysaccharide (lps)-induced ali, we decided to evaluate autophagy (by lc3-ii and autophagosome) and apoptosis (by caspase-3) at different time point...

L'œdème pulmonaire lésionnel aigue transfusionnel est une complication classique de la transfusion de produits sanguins labiles, responsable de 17% des décès liés à la transfusion. Il s'agit d'un syndrome de détresse respiratoire aiguë post-transfusionnel qui se présente comme un œdème pulmonaire aigu non cardiogénique survenant dans les six heures suivant la mise en oeuvre d'une transfusion sa...

lood transfusions are prevalent treatment procedures nowadays for various medical conditions that involve the administration of whole blood or separated components alone in combinations can be administered intravenously; these undertaken with therapeutic curative goals mind, they may carry associated risks and complications must weighed against benefits before initiating therapy. A typical subs...

(Accepted for publication March 16, 2015.) Center for Biologics Evaluation and Research, the putative cause of TRALI is anti–human leukocyte antigen or granulocyte antibodies in the donor blood product with 89% of TRALI cases having these antibodies.5 Clifford et al. did not present data on these antibodies, but the 2013 SHOT annual report suggested that antibodies were present in 40% of TRALI ...

Metastatic liver resection following cytoreductive chemotherapy is an accepted treatment for oligometastatic tumor diseases. Although pulmonary complications are frequently reported in patients undergoing liver surgery including liver transplantation, life-threatening acute respiratory failures in the absence of aspiration, embolism, transfusion-related acute lung injury (TRALI), pulmonary infe...

Transfusion-relatedacute lung injury (TRALI) is a form of posttransfusion acute pulmonary insufficiency that has been linked to the infusion of biologic response modifiers (BRMs), including antileukocyte antibodies and lipids. Soluble CD40 ligand (sCD40L) is a platelet-derived proinflammatory mediator that accumulates during platelet storage. We hypothesized that human polymorphonuclear leukocy...

Vascular endothelial cells regulate the passage of fluids, solutes, and cells from the vascular space to the tissues. Disruption of vascular integrity is involved in the pathogenesis of inflammatory diseases including transfusionrelated acute lung injury (TRALI), a most severe nonhemolytic transfusion reaction with symptoms such as dyspnea and/or hypotension and fever. Pulmonary edema, due to i...