purpose: to determine whether adding 2% topical cyclosporine (csa) to local and systemic steroids in treatment of endothelial corneal allograft rejection improves the outcome. methods: a prospective randomized treatment trial was carried out on 40 consecutive corneal graft recipients, presenting with the first episode of endothelial graft rejection in two groups. group one (20 patients) receive...

Background: Monitoring of phenotypic characteristics of T-lymphocytes in peripheral blood is commonly performed to give the clinical parameters in the management of kidney transplant recipients.   Objective: To predict rejection in renal transplantation by immune parameters. Methods: 16 non-diabetic kidney transplant candidates (4 females and 12 males, age = 20-65 yr, first time transplant) wer...

early wound excision and grafting of burn wounds is regarded not only as the method of choice in speeding up the healing process in deep burns, but also limits contracture and infection, on the other hand, smoking has generally been implicated in the delay of the healing process in a variety of surgical procedures, in this study we report the outcome of a cross-sectional study of all the 395 me...

corneal transplantation is the most common and successful form of solid organ transplantation with a 2-year survival rate of over 90% in low risk cases. this high success rate may be due to the immune privileged status of the cornea, acaid (anterior chamber associated immune deviation) induction phenomena and secretion of inhibitory molecules by corneal cells such as il1-ra, il-1a and fas ligan...

cyclosporine (csa) is a drug that has been used for prevention of kidney transplant rejection for many years. diltiazem with the inhibition of cyclosporine metabolism and clearance will increase csa concentration and csa dose can be decreased. the aim of this study was the evaluation of diltiazem effect on csa dose adjustment with respect to c2. forty stable renal transplant patients who were r...

Agent-based modeling has been used to characterize the nested control loops and non-linear dynamics associated with inflammatory and immune responses, particularly as a means of visualizing putative mechanistic hypotheses. This process is termed dynamic knowledge representation and serves a critical role in facilitating the ability to test and potentially falsify hypotheses in the current data-...