In the past few years, both laboratory investigations and population studies have provided strong circumstantial evidence that insulin-like growth factor (IGF) physiology influences cancer risk. In contrast to the influence of germ line mutations that are rare but are associated with very high risks, the impact of inter-individual variability in IGF physiology on risk appears to be modest but t...

Proteoglycans are abundant in the developing brain and there is much circumstantial evidence for their roles in directional neuronal movements such as cell body migration and axonal growth. We have developed an in vitro model of astrocyte cultures of the lateral and medial sectors of the embryonic mouse midbrain, that differ in their ability to support neuritic growth of young midbrain neurons,...

Within an isospin- and momentum-dependent hadronic transport model, it is shown that the recent FOPI data on the pi;{-}/pi;{+} ratio in central heavy-ion collisions at SIS/GSI energies [Willy Reisdorf, Nucl. Phys. A 781, 459 (2007)10.1016/j.nuclphysa.2006.10.085] provide circumstantial evidence suggesting a rather soft nuclear symmetry energy E_{sym}(rho) at rho> or =2rho_{0} compared to the Ak...

evidence based medicine (ebm) is a new approach to patient management which incorporates best evidence with the clinical expertise of the health care providers. although this approach has had a rapid growth in many clinical disciplines, its applications in radiology and nuclear medicine has not been addressed sufficiently. in this review ebm is briefly explained and the first two steps of the e...

This paper uses tools from argumentation and artificial intelligence to build a system to analyse reasoning from a motive to an action and reasoning from circumstantial evidence of actions to a motive. The tools include argument mapping, argumentation schemes, inference to the best explanation and a hybrid method of combining argument and explanation. Several examples of use of relevant motive ...

An outbreak of syndrome unknown etiology associated with the feeding moldy dry forage and green fodder among goats in Dhakeri village Banke District on October-November 2008. Goats suddenly became ill symptoms knuckling fetlocks pelvic limbs, no apparent ataxia or flexor weakness. Weight bearing was possible while digits were extended, but knuckling, weight supported dorsal surface foot. The mo...

Palaeozoic hypercalcified sponges were ubiquitous Ordovician—Devonian reef builders but, despite their rich fossil record, original skeletal mineralogy and microstructure remain poorly understood. This study provides the first application of electron backscatter diffraction (EBSD) to analyse structure Silurian Devonian stromatoporoids. The two stromatoporoid taxa selected are typical stromatopo...