Prourokinase (proUK) is a zymogenic plasminogen activator that at pharmacological doses is prone to nonspecific activation to urokinase. This has handicapped therapeutic exploitation of its fibrin-specific physiological properties. To attenuate this susceptibility without compromising specific activation of proUK on a fibrin clot, a Lys300-->His mutation (M5) was developed. M5 had a lower intri...

Model trees are tree-based regression models that associate leaves with linear regression models. A new method for the stepwise induction of model trees (SMOTI) has been developed. Its main characteristic is the construction of trees with two types of nodes: regression nodes, which perform only straight-line regression, and splitting nodes, which partition the feature space. In this way, intern...

Model trees are tree-based regression models that associate leaves with linear regression models. A new method for the stepwise induction of model trees (SMOTI) has been developed. Its main characteristic is the construction of trees with two types of nodes: regression nodes, which perform only straight-line regression, and splitting nodes, which partition the feature space. In this way, intern...