In a recent preliminary note2 concerning electrical correlates of peripheral nerve injury, it was pointed out that the condition of peripheral nerves is reflected in the changing surface potential differences. The following discussion will briefly describe certain experiments which led to this observation and to the clinical application of the method in cases where there is any question of peri...

Spinal cord injury (SCI) is a devastating condition that affects many people worldwide. Treatment focuses on controlling secondary injury cascade and improving regeneration. It has recently been suggested that both the secondary injury cascade and the regenerative process are heavily regulated by microRNAs (miRNAs). The measurement of specific biomarkers could improve our understanding of the d...

Kidney disease is a devastating condition that affects millions of people worldwide, and its prevalence is predicted to significantly increase. The kidney is a complex organ encompassing many diverse cell types organized in a elaborate tissue architecture, making regeneration a challenging feat. In recent years, there has been a surge in the field of stem cell research to develop regenerative t...

Bone has multiple functions, both morphologically and physiologically, and it frequently features in the pathological condition, including fracture and osteoporosis. For bone regeneration therapy, the regulation of osteoblast differentiation is important. MicroRNA (miRNA)s are short noncoding RNA which regulate gene expression at the post-transcriptional level. MiRNAs play an important role not...

Chronic obstructive pulmonary disease (COPD) is a critical condition with high morbidity and mortality. Although several medications are available, there are no definite treatments. However, recent advances in the understanding of stem and progenitor cells in the lung, and molecular changes during re-alveolization after pneumonectomy, have made it possible to envisage the regeneration of damage...

Tadpoles of the bullfrog Rana catesbeiana lose the ability to regenerate limbs amputated through the femur at a very early stage in development. Well-differentiated limbs which in other species can regenerate if amputated through the ankle, cannot in this species. Nonregenerating tadpole limbs either show rapid healing of the cut surface by connective tissue with no breakdown of skeletal struct...

BACKGROUND This is the first ever decade which has witnessed the emergence of a highly lethal condition termed acute-on-chronic liver failure (ACLF), which today is the leading cause of death compared to acute and chronic liver failure. However, the complex pathophysiology of ACLF remains poorly understood. This article will attempt to summarize recent progress in the understanding of the mecha...

central nervous system axons fail to regenerate after spinal cord injury (sci), partially due to the accumulation of extracellular matrix molecules in the lesion and formation of the glial scar. depakine, as known as histone deacetylase inhibitor, has neuroprotective effects. this study evaluated the histological changes (cavitation and axon regeneration) after sci associated with (following ad...

strawberry is a valuable, nutritious, and economically important fruit all over the world including bangladesh. therefore, there is a demand to develop a suitable variety of strawberry. for this purpose, leaf explants from in vitro grown strawberry plantlets were cultured onto ms medium supplemented with different concentrations and combinations of 2,4-d, naa and ba for callus induction. the mo...

In the last few years various methods are being applied in the use of platelet-rich plasma (PRP) during treatment in different orthopedic disease and sports trauma. They allow im‐ provement of local biological condition and regeneration of different types of tissues. PRP is a modern treatment strategy with worldwide recognition. There is a high concen‐ tration of platelet growth factors in smal...