1.5 CPET Protocols Cardiopulmonary exercise testing (CPET) provides a global as-1.6 Treatment of the Data sessment of the integrative exercise responses involving the pul-1.7 Validation monary, cardiovascular, hematopoietic, neuropsychological, and 1.8 Statistical Treatment of the Data skeletal muscle systems, which are not adequately reflected 2. Alternative Approach to Obtain Normal Reference...

Current generative frameworks use end-to-end learning and generate images by sampling from uniform noise distribution. However, these approaches ignore the most basic principle of image formation: images are product of: (a) Structure: the underlying 3D model; (b) Style: the texture mapped onto structure. In this paper, we factorize the image generation process and propose Style and Structure Ge...

This paper proposes algorithms for learning two-level Boolean rules in Conjunctive Normal Form (CNF, i.e. AND-of-ORs) or Disjunctive Normal Form (DNF, i.e. OR-of-ANDs) as a type of human-interpretable classification model, aiming for a favorable trade-off between the classification accuracy and the simplicity of the rule. Two formulations are proposed. The first is an integer program whose obje...

Despite overwhelming evidence implicating the prion protein (PrP) in prion disease pathogenesis, the normal function of this cell surface glycoprotein remains unclear. In previous reports we demonstrated that PrP mediates cellular iron uptake and transport, and aggregation of PrP to the disease causing PrP-scrapie (PrP(Sc)) form results in imbalance of iron homeostasis in prion disease affected...

Latent endometrial carcinoma precancers are normal-appearing endometrial glands with sporadic loss of tumor suppressor gene function such as PTEN. Progression to carcinoma is inefficient and requires additional genetic damage that creates a histologic precursor lesion called endometrial intraepithelial neoplasia (EIN). In this study, we examined loss of PAX2 expression, a gene required for embr...

Different regions of mammalian skin vary in characteristics such as thickness, and hair follicle sweat gland presence, size density, that are reflected differential responses to injury disease. Positional information resides the upper dermis but responsible molecular mechanisms poorly understood. To uncover these, we carried out comparative scRNA-seq mouse embryonic dorsal, ear plantar skin. Th...