Rather than investigate whether paternal leukocyte immunization improves the live birth rate in women with three or more abortions, we analysed the results of patients expected to have a poor outcome in a subsequent pregnancy if untreated, i.e. women with five or more abortions and no anti-paternal complement-dependent antibody (APCA) at initial testing. The analysis included the results of pat...

BACKGROUND Recurrent spontaneous abortion (RSA) is defined as three or more sequential abortions before the twentieth week of gestation. There are evidences to support an allo-immunologic mechanism for RSA. One of the methods for treatment of RSA is leukocyte therapy; however there is still controversy about effectiveness of this method. OBJECTIVES To evaluate the effectiveness of leukocyte t...

OBJECTIVE To examine psychosocial predictors of successful pregnancy after recurrent spontaneous abortions (RSA). METHOD We administered two waves of semi-structured interview and self-report questionnaire battery to a consecutive series of 46 couples who had had two RSAs (baseline before third pregnancy, and immediately after third pregnancy was ascertained), and followed them through their ...

spontaneous abortion (sab) is the most common complication of early pregnancy. numerous risk factors are associated with an increased risk of pregnancy loss such as: blighted ovum. the aim of this study was to determine the frequency of balanced chromosomal translocations in couples with a history of recurrent spontaneous abortions and ultrasound diagnosed blighted ovum. sixty eight couples wit...

Introduction: A factor known to cause thrombophilia in women with recurrent pregnancy loss (RPL) is the A1298C polymorphism of methylenetetrahydrofolate reductase gene (MTHFR). This study aimed to determine the association between RPL and this polymorphism in Iranian patients. Methods: In this case-control study, 30 patients with a previous history of two or more consecutive unexplained abortio...

Background: Recurrent spontaneous abortion (RSA) is usually defined as three or more consecutive pregnancy losses before 20th week of gestation. Although different factors are considered as etiology of RSA but in some cases, despite of extensive work up, the cause of RSA remains unknown which called unexplained RSA. Immunological factors are suggested as etiological factors of unexplained RSA. ...

By selecting chromosomally normal embryos for replacement, PGD for aneuploidy can (i) increase implantation rates, (ii) reduce spontaneous abortion rates, and (iii) avoid aneuploid conceptions. When eight chromosomes are analysed, a significant increase in implantation is achieved. PGD is also found to significantly reduce the incidence of spontaneous abortion and chromosomally abnormal concept...

Single-nucleotide polymorphisms are a type of genetic variation that may be utilized to investigate illness vulnerability. Recurrent abortion is linked hereditary thrombophilias, which include various disorders such as the MTHFR thermolabile variation. No link known between these two mutations and risk recurrent spontaneous abortion. It unknown if pregnant women with at losing their baby. Thirt...

The liver X receptors (LXRs) have been shown to be crucially involved in maternal-fetal cholesterol transport and placentation. The aim of this study was to investigate the expression pattern and frequency of LXR under normal physiological circumstances and in spontaneous abortion and/or recurrent miscarriage. A total of 29 (12 physiologic pregnancies/10 spontaneous abortions/7 recurrent miscar...