OBJECTIVE To study the correlation of randomly-tested total antiepileptic plasma levels and seizure control in a retrospectively collected group of pregnant epileptic Saudi women. METHODS The medical records of 30 Saudi epileptic female patients were reviewed during their subsequent pregnancies (total of 50). The type of antiepileptic drugs used during each pregnancy, the dose of each drug an...

BACKGROUND Febrile convulsions, or febrile seizures, are frequently encountered in paediatrics, and despite often being self limiting, these seizures strike fear in the hearts of patients' carers. OBJECTIVE This article reviews the assessment and management of febrile seizures in children. DISCUSSION The initial assessment of a child who convulses with fever should be directed at finding a ...

OBJECTIVE To present a case of intractable cryptogenic gelastic epilepsy with ictal video-EEG to localize the seizure focus. CLINICAL PRESENTATION AND INTERVENTION A 39-year-old female presented with a 2-year history of intractable gelastic epilepsy characterized by recurrent episodes of stereotyped pathological laughter, transient unresponsiveness, automatisms and brief postictal confusion. ...

Approximately 1% of the global population suffers from epilepsy, a class of disorders characterized by recurrent and unpredictable seizures. Of these cases roughly one-third are refractory to current antiepileptic drugs, which typically target neuronal excitability directly. The events leading to seizure generation and epileptogenesis remain largely unknown, hindering development of new treatme...

A 23 years old female presented with recurrent episode of left hemiparesis for 6 months. Each episode lasted for 10 to 20 min at interval of 15 to 20 days. These episodes of weakness were not associated with any seizure like activity, unconsciousness or other focal neurological deficit. Three days back patient had recurrent left sided focal motor seizure with secondary generalization. She had p...

Pyridoxine-dependent epilepsy (PDE) is a rare disease characterized by mutations in the lysine degradation gene ALDH7A1 leading to recurrent neonatal seizures, which are uniquely alleviated by high doses of pyridoxine or pyridoxal 5'-phosphate (vitamin B6 vitamers). Despite treatment, neurodevelopmental disabilities are still observed in most PDE patients underlining the need for adjunct therap...

OBJECTIVES There is controversy regarding the need for invasive monitoring in the preoperative assessment of patients with temporal lobe epilepsy. The use of a series of non-invasive investigations in identifying the seizure focus is reported in 75 consecutive adults referred for epilepsy surgery. METHODS All had video-EEG monitoring using scalp electrodes, high resolution MRI, and neuropsych...

Magnetic resonance imaging (MRI)-negative epilepsy is associated with poor clinical outcomes prognosis. The present study was aimed to assess whether intracranial 3D interictal and ictal electroencephalography (EEG) findings, a combination of EEG at a different depth, in addition to clinical, scalp EEG, and positron emission tomography-computed tomography (PETCT) data help to predict outcome in...

Epilepsy is one of the common neurological disorders characterized by a sudden and recurrent malfunction of the brain that is termed “seizure”, affecting over 50 million individuals worldwide. The Electroencephalogram (EEG) is the most influential technique in detection of epileptic seizures. In recent years, many research works have been devoted to the detection of epileptic seizures based on ...

Electroencephalographic recordings in dogs: prevention of muscle artifacts and evaluation of two activation techniques in healthy individuals. Res Vet Sci. Article in Press. Electroencephalographic recordings in dogs suffering from idiopathic and symptomatic epilepsy: diagnostic value of interictal short time EEG protocols supplemented by two activation techniques. Submitted. Paroxysmal dischar...