BACKGROUND The ocular presentation of Castleman's disease (CD)-associated paraneoplastic pemphigus (PNP) has rarely been reported. In this report, we describe a young patient with CD-associated PNP who had recurrent corneal ulceration in addition to cicatrizing conjunctivitis. CASE PRESENTATION We describe a case of 23-year-old male with mucocutaneous erosion and conjunctival injection and er...

The standard treatment for pterygium was surgical excision with bare sclera technique which was associated with a high recurrence rate. Therefore adjunct treatment options are used to reduce this recurrence, such as the use of beta radiation, conjunctiva auto graft, amniotic membrane grafting and mitomycin C (1,2). Pterygium recurrence is one of the challenging problem facing ophthalmologists d...

Simple excision of pterygium, although very simple, is associated with variable postoperative recurrence rate which is especially high with bare sclera technique [1,2]. Recurrence of pterygium could be attributed to episcleral fibroblasts proliferation and neovascularization secondary to the traumatic and inflammatory processes following pterygium surgery. Histologically, pterygium comprises a ...

PURPOSE To investigate the effect of pterygium surgery on corneal topography and contrast sensitivity. PATIENT AND METHODS The IRB approved this prospective, nonrandomized, self-controlled study. Computerized videokeratography (Orbscan II) was performed in 36 patients with primary pterygia, both before and 1 month after pterygium excision with limbal-conjunctival autografting. The topographic...

Recurrence of pterygium is the main concern for ophthalmic surgeons after the excision of pterygium. To evaluate the efficacy and safety of ethanol treatment during pterygium excision in preventing the recurrence of pterygia. A prospective randomized study was performed of 78 eyes in primary pterygium patients treated by excision. Primary pterygium patients were randomly assigned to ethanol gro...

PURPOSE To examine the expression pattern of insulin-like growth factor-binding protein (IGFBP)-2 in cultured primary pterygium fibroblasts and compare it with expression in normal conjunctival fibroblasts. METHODS Profile of gene expression by normal conjunctival and primary pterygium fibroblasts was performed by using a cDNA microarray. The overexpression of IGFBP-2 thus identified was furt...

BACKGROUND Pterygium is a common chronic ophthalmic condition, which may result in significant visual morbidity or lead to blindness in extreme cases. The prevalence of pterygium in China has not been reported at the sub-national level. METHODS In this study, we conducted a systematic review and meta-analysis to estimate the prevalence of pterygium in China. China National Knowledge Infrastru...

PURPOSE To investigate the expression of SPARC and matrix metalloproteinases (MMPs) in normal conjunctiva and pterygium tissues. METHODS This study involved paired control or uninvolved conjunctiva and pterygium tissue from 21 patients. Quantitative real-time PCR was performed to assess SPARC and MMP mRNA expression, whereas Western blot analysis was performed to assess SPARC protein levels i...

INTRODUCTION Pterygium is a fibrous growth seen in bulber conjunctiva.It is a non malignant growth which may cause visual impairment. MATERIAL AND METHODS Pterygium study was done on rural population in out patient department of NIMS Hospital and medical college, Jaipur, Rajasthan, India.Two hundred patients with 300 eyes which had Pterygium who attended the Eye OPD during 01/06/2011 to 01/03...

PURPOSE To evaluate the risk factors for pterygium in the dry, high altitude province of Ilam, Iran. METHODS The study included patients who presented to ophthalmology clinic. The patients were divided into two groups: 210 diagnosed with pterygium or pinguecula (unilateral or bilateral), and 210 healthy controls. Demographic variables, living environment, disease type, disease laterality, fam...