AIM OF THE STUDY To evaluate outcome, costs and treatment differences in rectal cancer patients between various regions in Poland. MATERIAL AND METHODS Data from the Polish National Health Fund of all patients with rectal cancer diagnosed and treated between 2005 and 2007 were analyzed. Overall, relative 5-year survival and the percentage of patients receiving chemotherapy, radiotherapy and s...

Introduction: Rectal toxicity is a dose limiting issue in prostate cancer radiotherapy. Prediction of these effects may be used to tailor the therapy. The purpose of this work was to develop predictive radiomic models based on clinical, dosimetric and radiomic features extracted from rectal wall magnetic resonance image (MRI).   Materials and Methods: This st...

We studied the association between dietary folate and specific K-ras mutations in colon and rectal cancer in The Netherlands Cohort Study on diet and cancer. After 7.3 years of follow-up, 448 colon and 160 rectal cancer patients and 3,048 sub-cohort members (55-69 years at baseline) were available for data analyses. Mutation analysis of the K-ras gene was carried out on all archival adenocarcin...

BACKGROUND AND AIMS Nodal metastases are indisputable determinants of prognosis for colon and rectal cancer. Using classical histological criteria, many attempts to predict nodal metastasis have failed, preventing the adequate management of stage I (pT1) cancer. We investigated the role of tumour matrilysin in predicting metastatic potential, and discuss its potential use in individualising tre...

Background: There may be a weak association between total alcohol intake and colorectal cancer but the effect of different types of alcohol and effect on colon subsites have not been investigated satisfactorily. Aims: To investigate the relationship between amount and type of alcohol and the risk of colon and rectal cancer. Subjects: A population based cohort study with baseline assessment of w...

INTRODUCTION The results of total mesorectal excision (TME) for rectal cancer were first reported 20 years ago. The superior outcome in the original two papers was attributed to the complete excision of the mesorectum, preference for anterior resection over abdominoperineal resection, application of cytotoxic solutions to eradicate exfoliated tumour cells and specialisation in rectal cancer sur...

conclusions cpaa provided not only better functional results than scaa, but also improved quality of life, thus may be the better choice. background the tendency towards sphincter preserving for low rectal cancers with low anterior resection, has led to the technique of straight coloanal anastomosis (scaa) or colonic j-pouch anal anastomosis (cpaa). objectives the aim of our study was to compar...

background: colorectal carcinoma is the third most common cause of death in iran. this study was performed in order to determine the appropriate distal clearance margin (dcm) for resection of rectal cancer in patients who undergo neoadjuvant chemoradiotherapy for sphincter preserving procedure. materials and methods: this was a cross-sectional study conducted in shahid faghihi hospital of shira...

PURPOSE Lymph-node metastasis is the most important predictor of survival in stage III rectal cancer. The number of metastatic lymph nodes may vary depending on the level of specimen dissection and the total number of lymph nodes harvested. The aim of this study was to evaluate whether the lymph node ratio (LNR) is a prognostic parameter for patients with rectal cancer. METHODS A retrospectiv...