نتایج جستجو برای: recombinant tissue plasminogen activator rtpa

تعداد نتایج: 1042975  

Journal: :European neurology 2009
Maurizio Paciaroni Valeria Caso Giancarlo Agnelli

Ischemic penumbra was first defined by Astrup in 1981 as perfused brain tissue at a level within the thresholds of functional impairment and morphological integrity, which has the capacity to recover if perfusion is improved. It exists, even for a short period of time in the center of ischemia, from which irreversible necrosis propagates to the neighboring tissues over time. Penumbra has become...

Journal: :Stroke 2011
Neal Naff Michael A Williams Penelope M Keyl Stanley Tuhrim M Ross Bullock Stephan A Mayer William Coplin Raj Narayan Stephen Haines Salvador Cruz-Flores Mario Zuccarello David Brock Issam Awad Wendy C Ziai Anthony Marmarou Denise Rhoney Nichol McBee Karen Lane Daniel F Hanley

BACKGROUND AND PURPOSE Patients with intracerebral hemorrhage and intraventricular hemorrhage have a reported mortality of 50% to 80%. We evaluated a clot lytic treatment strategy for these patients in terms of mortality, ventricular infection, and bleeding safety events, and for its effect on the rate of intraventricular clot lysis. METHODS Forty-eight patients were enrolled at 14 centers an...

Journal: :AJNR. American journal of neuroradiology 2008
T C Burns G J Rodriguez S Patel H M Hussein A L Georgiadis K Lakshminarayan A I Qureshi

BACKGROUND AND PURPOSE Since the introduction of recombinant tissue plasminogen activator (rtPA) into clinical practice in the mid 1990s, no adjunctive treatment has further improved clinical outcomes in patients with ischemic stroke. The safety, feasibility, and efficacy of combining intravenous (IV) rtPA with endovascular interventions has been described; however, no direct comparative study ...

Journal: :Stroke 2005
David M Kent Lori Lyn Price Peter Ringleb Michael D Hill Harry P Selker

BACKGROUND AND PURPOSE Women experience worse outcomes after stroke compared with men. Prior work has suggested sex-based differences in coagulation and fibrinolysis markers in subjects with acute stroke. We explored whether sex might modify the effect of recombinant tissue plasminogen activator (rtPA) on outcomes in patients with acute ischemic stroke. METHODS Using a combined database inclu...

2017
Johann Otto Pelz Dominik Michalski Dorothee Saur

Systemic thrombolysis with the recombinant tissue plasminogen activator (rtPA) is an effective therapy option in the treatment of acute ischaemic stroke [1]. A rare but potentially fatal side effect is the development of an orolingual angioedema [2]. Because of improvements in acute stroke therapy and an aging population the incidence of recurrent strokes is increasing and results in more patie...

Journal: :Archives of neurology 2007
Enrique C Leira Jennifer K Pary Patricia H Davis Karla J Grimsman Harold P Adams

BACKGROUND In the rural United States, patients with stroke are usually first evaluated locally by a nonneurologist physician (NNP) before treatment is determined. OBJECTIVE To determine the evolution of NNPs' familiarity and attitudes about using recombinant tissue plasminogen activator (rtPA) since this therapy has been approved. DESIGN Cross-sectional design using 2 similar surveys maile...

Journal: :Stroke 1999
M Andersen K Overgaard P Meden G Boysen S C Choi

BACKGROUND AND PURPOSE We sought to evaluate the effects of the combination of cytidine-5'-diphosphocholine (citicoline) and thrombolysis on infarct size, clinical outcome, and mortality in a rat embolic stroke model. METHODS Eighty-three Sprague-Dawley rats were embolized in the carotid territory with a single fibrin embolus and randomly assigned to the following treatment groups: (1) contro...

Journal: :The Journal of clinical investigation 1986
A Ichinose K Takio K Fujikawa

Functionally active A and B chains were separated from a two-chain form of recombinant tissue-type plasminogen activator after mild reduction and alkylation. The A chain was found to be responsible for the binding to lysine-Sepharose or fibrin and the B chain contained the catalytic activity of tissue-type plasminogen activator. An extensive reduction of two-chain tissue-type plasminogen activa...

2010
Ramin Nourinia Mohammad Hossein Jabbarpour Bonyadi Hamid Ahmadieh

PURPOSE To evaluate the results of intravitreal expansile gas injection, with or without recombinant tissue plasminogen activator (rtPA), followed by intravitreal bevacizumab injection for treatment of submacular hemorrhage (SMH) secondary to neovascular age-related macular degeneration (AMD). METHODS In this interventional case series, 5 eyes of 5 patients with SMH secondary to choroidal neo...

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