نتایج جستجو برای: recombinant escherichia coli

تعداد نتایج: 254241  

Background: The production of recombinant proteins in Escherichia coli is one of the most valuable achievements in biotechnology, with many therapeutic and diagnostic applications; however, the aggregation and misfolding of proteins that result in the formation of insoluble inclusion bodies is a disruptive factor in this process. Various solubilization and refolding methods can be used to impro...

Journal: :BioTechniques 1998
M J Ausserlechner R Sgonc G Wick

1.Dong, H., L. Nilsson and C.G. Kurland. 1995. Gratuitous overexpression of genes in Escherichia coli leads to growth inhibition and ribosome destruction. J. Bacteriol. 177:1497-1504. 2.Kim, J.-Y., H.A. Kang and D.D.Y. Ryu. 1993. Effects of the par locus on the growth rate and structural stability of recombinant cells. Biotechnol. Prog. 9:548-554. 3.Kumar, P.K.R., H.-E. Maschke, K. Friehs and K...

2011
Tomohiro Makino Georgios Skretas George Georgiou

Protein expression in Escherichia coli represents the most facile approach for the preparation of non-glycosylated proteins for analytical and preparative purposes. So far, the optimization of recombinant expression has largely remained a matter of trial and error and has relied upon varying parameters, such as expression vector, media composition, growth temperature and chaperone co-expression...

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