In plants, perception of invading pathogens involves cell-surface immune receptor kinases. Here, we report that the Arabidopsis SITE-1 PROTEASE (S1P) cleaves endogenous RAPID ALKALINIZATION FACTOR (RALF) propeptides to inhibit plant immunity. This inhibition is mediated by the malectin-like receptor kinase FERONIA (FER), which otherwise facilitates the ligand-induced complex formation of the im...

the insulin-like growth factor i receptor (igf-ir) plays an essential role in the establishment and maintenance of transformed phenotype. interference with the igf-ir pathway by antisense causes reversal of the transformed phenotype in many rodent and human tumor cell lines. we stably transfected the pc-3 human prostate cancer cell line with an igf-ir antisense rna expression plasmid. the numbe...

background: the pathogenesis of inflammatory bowel disease is complex and multifactorial. studies have led to the current concept that toll-like receptors represent key mediators of innate host defense in the intestine, and they are involved in maintaining mucosal as well as commensal homeostasis. we studied the possibility of simvastatin and antagonist of receptors of interleukin-1 for pharmac...

We identified in deepwater rice (Oryza sativa L.) a gene encoding a leucine-rich repeat receptor-like transmembrane protein kinase, OsTMK (O. sativa transmembrane kinase). The transcript levels of OsTMK increased in the rice internode in response to gibberellin. Expression of OsTMK was especially high in regions undergoing cell division and elongation. The kinase domain of OsTMK was enzymatical...

Glial cell line-derived neurotrophic factor (GDNF) is released by glioma cells and promotes tumor growth. We have previously found that GDNF from the a chemoattractant for microglial cells, immune of central nervous system. Here we show increases matrix metalloproteinase (MMP) 9 MMP14 expression in cultured mixed sexes neonatal mice. The GDNF-induced MMP9 upregulation mediated family receptor a...

Receptor-like kinase complexes in plant innate immunity Greeff, Michael Christiaan; Roux, Milena Edna; Mundy, John; Petersen, Morten Published in: Frontiers in Plant Science DOI: 10.3389/fpls.2012.00209 Publication date: 2012 Document Version Publisher's PDF, also known as Version of record Citation for published version (APA): Greeff, M. C., Roux, M. E., Mundy, J., & Petersen, M. (2012). Recep...

Abstract Heparin-Binding EGF-like Growth Factor (HB-EGF) is a ligand for the Epidermal Receptor (EGFR), tyrosine kinase receptor which promotes cell proliferation and migration. In epithelium of lung, HB-EGF an important factor wound repair, however little known about effects on viral infection in vivo. Literature suggests that human alveolar epithelial lines, EGFR cofactor Influenza A infectio...