We used a free-recall paradigm to establish a behavioral index of the retrograde and anterograde interference of emotion with episodic memory encoding. In two experiments involving 78 subjects, we show that negatively valenced items elicit retrograde amnesia, whereas positively valenced items elicit retrograde hypermnesia. These data indicate item valence is critical in determining retrograde a...

Behavioral and biochemical studies suggest that dopamine (DA) plays a role in the reinforcing and addictive properties of drugs of abuse. Recently, this hypothesis has been challenged on the basis of the observation that, in mice genetically lacking the plasma membrane dopamine transporter [DAT-knock out (DAT-KO)], cocaine maintained its reinforcing properties of being self-administered and ind...

Hypothesis / aims of study Duloxetine and reboxetine are two drug that inhibit reuptake of norepinephrine and increase norepinephrine levels in the central nervous system. Both drugs have shown clinical efficacy in the treatment of stress urinary incontinence (1). It is still unclear, however, how increases in norepinephrine can modulate urethral sphincter activity. Spinal motoneurons of Onuf’s...

1.0 Introduction 1.1 Purpose 1.2 Causes of excessive sleepiness 2.0 Background 3.0 Methods 3.1 Literature search strategy 3.2 Evidence review 4.0 Results 4.1 Treatment of hypersomnia due to narcolepsy with or without cataplexy 4.1.1 Medications 4.1.1.1 Amphetamine, methamphetamine, dextroamphetamine methylphenidate, and related preparations 4.1.1.2 Modafinil and armodafinil 4.1.1.3 Sodium oxyba...

There is a long-standing assumption that low noradrenergic activity during sleep reflects mainly the low arousal during this brain state. Nevertheless, recent research has demonstrated that the locus coeruleus, which is the main source of cortical noradrenaline, displays discrete periods of intense firing during non-REM sleep, without any signs of awakening. This transient locus coeruleus activ...