PURPOSE The anti-MUC1 monoclonal antibody (MAb), PAM4, has a high specificity for pancreatic adenocarcinoma compared with other cancers, normal tissues, or pancreatitis. In order to assess its role in early pancreatic cancer development, we examined the expression of the PAM4-reactive MUC1 in the noninvasive precursor lesions, pancreatic intraepithelial neoplasia (PanIN) and intraductal papilla...

Systemic SarcoidosisWith Unique Vulvar Involvement Sarcoidosis is a complex, multisystem disease with an unclear cause.1 Research suggests that the pathogeneticmechanism of sarcoidosis is dysregulation of the immune system in individuals with a genetic predisposition who are subsequently exposed to inciting environmental agents.2 Cutaneous sarcoidosis is often one of the earliest clinical signs...

Introduction Gingival growths are one of the most frequently encountered lesions in the oral cavity. Most of these lesions, such as irritational fibroma, pyogenic granuloma, peripheral ossifying fibroma and peripheral giant cell granuloma, are innocuous and rarely present with aggressive features. In majority of cases, these lesions are the result of trauma or chronic irritation. One of the inf...

Hemangioma is a rare, non-reactive, benign vascular tumor, characterized by endothelial cell proliferations and results from malformation. mostly occurs on head neck skin regresses spontaneously within 5-10 years in 50-90% of cases. However, oral lesions show less regression than lesions. The most commonly affected area tongue palatal mucosa, rarely observed jaw bones. Diagnosis based anamnesis...

Introduction: Herpes Simplex Virus type 1 (HSV-1) is the virus that most often infects oral cavity. HSV-1 in latent phase migrates to trigeminal ganglion after primary infection and can reactivate cause recurrent intraoral herpes (RIH). The recurrence of RIH multifactorial triggered by decreased immunity, fatigue, hypersensitivity, stress, ultraviolet. Case: Three male patients came Oral Diseas...

BACKGROUND/AIM To investigate the relative frequency of biopsied nonneoplastic oral mucosal lesions in Ankara, Turkey. MATERIALS AND METHODS Biopsy records of a single center from 2000-2012 were retrospectively collected. Diagnosis was recorded and evaluated with respect to patient demographics (age, sex) and location of the lesion. RESULTS Of 11,980 biopsies, 1732 (14.5%) were mucosal nonn...

Multiple sclerosis is a chronic inflammatory disease of the central nervous system, associated with demyelination and neurodegeneration. The mechanisms of tissue injury are poorly understood, but recent data suggest that mitochondrial injury may play an important role in this process. Mitochondrial injury can be triggered by reactive oxygen and nitric oxide species, and we recently provided evi...

BACKGROUND The measurement of serum thyroglobulin (Tg) is widely used as a marker for recurrence of thyroid carcinoma following total thyroidectomy. However, this method cannot differentiate between benign and malignant disease. We focused on the sugar chain in the Tg molecule and investigated the usefulness of Lens culinaris agglutinin (LCA)-reactive Tg ratios in sera and wash fluids obtained ...

PURPOSE Pyogenic Granuloma (PG) is an inflammatory hyperplasia which is non-neoplastic in nature. Because of the high incidence of oral PG, critical need exists for its proper diagnosis and treatment. Peripheral Ossifying Fibroma (POF) is a focal reactive overgrowth occurring in young adults. Though clinically similar to PG, it is important to differentiate the lesions based on the histopathol...

trans-4-Acetylaminostilbene is acutely toxic to the glandular stomach and produces sebaceous gland tumors in rats quite specifically. Metabolism, tissue exposure to reactive metabolites, DNA binding and persistence of DNA lesions are implicated in tissue susceptibility, but nothing indicates that one of these parameters determines the biological effect. All tissues are exposed to reactive metab...