The concept of “reverse cholesterol transport” (RCT) was first introduced in 1968 by Glomset1 to describe the process by which extrahepatic (peripheral) cholesterol is returned to the liver for excretion in the bile and ultimately the feces. The physiological need for this process is clear, as nonhepatic cells acquire cholesterol through uptake of lipoproteins and de novo synthesis and yet (wit...

OBJECTIVES To assess the external validity of a pragmatic, investigator-initiated RCT on treatment of severe infections caused by methicillin-resistant Staphylococcus aureus (MRSA), we compared patient characteristics and treatment effect estimates for patients included in the RCT versus those excluded. PARTICIPANTS AND OUTCOMES The RCT included hospitalised patients with documented or highly...

OBJECTIVE Chymase released by activated mast cells degrades high-density lipoproteins. We evaluated whether local activation of mast cells would attenuate cholesterol efflux from neighboring macrophage foam cells, thereby disrupting the entire in vivo pathway of macrophage-specific reverse cholesterol transport (RCT). METHODS AND RESULTS C57Bl/6J mice received intraperitoneal injections of th...

OBJECTIVES Compared with controls, multiple sclerosis (MS) patients die, on average, 7-14 years prematurely. Previously, we reported that, 21 years after their participation in the pivotal randomised, controlled trial (RCT) of interferon β-1b, mortality was reduced by 46-47% in the two groups who received active therapy during the RCT. To determine whether the excessive deaths observed in place...

the root canal treatment (RCT) prognosis. The successful RCT prevents tooth loss and avoids pain and apical periodontitis. This review aimed to categorize common operative procedure errors and clinical factors associated with RCT. Based on this, will be approached common errors of procedures within the clinical operative sequence: endodontic treatment planning, pulp and periapical disease diagn...

The propagation of flexural waves across a gap of finite width in an infinite ice sheet is solved using the residue calculus technique (RCT). The boundary value problem is defined by a thin elastic plate equation coupled with hydrodynamic effects from inviscid and incompressible fluid under the plate. The method of solution is based on the recent application of the RCT to the semi-infinite ice ...

One example of the use of an RCT in public policy, as opposed to the health sector, involves sending message reminders to those with unpaid court fines. The Court Service and Behavioural Insights Team randomly allocated individuals to a control group, to whom no text message were sent, and to other groups sent text message reminders with or without personalised information. This RCT demonstrate...

In order for rational choice theory (RCT) to explain the production of collective action, it must be able to distinguish between two behaviorally identical possibilities: one, that all of the agents in a group are each performing behaviors in pursuit of a set of individual actions; and two, that all of those agents are performing those behaviors in pursuit of a collective action. I argue that t...

The most generally accepted and best documented manipulation in procedural justice experiments is varying whether or not participants are allowed an opportunity to voice their opinion about a decision. To better understand the psychology of voice, the authors focus on Referent Cognitions Theory (RCT). It is argued that thus far RCT has not been used to explain the psychology of voice and that p...

The ability of temperature variants of influenza A2 virus to produce plaques in chick embryo kidney tissue culture was studied at different temperatures. Definite differences in efficiency of plaque formation by cryophilic and thermophilic strains were observed at low and high temperatures. Differentiation of the temperature variants appears to reside in a number of genetic markers, designated ...