CONTEXT Women with previous gestational diabetes mellitus (pGDM) are at high risk of developing type 2 diabetes mellitus in the future. The role of adipokines in women with pGDM has not been established. OBJECTIVE We investigated whether circulating adipokine concentration is associated with abnormal glucose homeostasis in women with pGDM. DESIGN, SETTING, PATIENTS, AND MAIN OUTCOME MEASURES:...

AIMS/HYPOTHESIS The excessive accumulation of adipose tissue in the obese state is linked to an altered secretion profile of adipocytes, chronic low-grade inflammation and metabolic complications. RBP4 has been implicated in these alterations, especially insulin resistance. The aim of the present study was to determine if a local inflammatory micro-environment in adipose tissue regulates RBP4 e...

One of the most common public liver diseases over world is fatty which contain alcoholic and non-alcoholic liver. One-fourth among general population are impact Non-Alcoholic Fatty Liver Disease (NAFLD) in worldwide.Retinol binding protein 4 (RBP4) known as an adipokine, mainly synthesized secreted from form adipose tissues. RBP4 acts a transporter specifically bound to retinol others Visfatin ...

OBJECTIVE Serum retinol binding protein 4 (RBP4) is a new liver- and adipocyte-derived signal that may contribute to insulin resistance. Therefore, the RBP4 gene represents a plausible candidate gene involved in susceptibility to type 2 diabetes. RESEARCH DESIGN AND METHODS In this study, the RBP4 gene was sequenced in DNA samples from 48 nonrelated Caucasian subjects. Five novel and three kn...

Aims/Introduction: The RBP4 level has been found to correlate positively with risk of insulin resistance and type 2 diabetes. However, the exact mechanism linking RBP4 with metabolic disorders is not clear. In presented study the associations of two single nucleotide polymorphisms located in promoter region of the RBP4 gene rs3758538 (1265A>C) and rs3758539 (-803 G>A) with insulin resistance ri...

Plasma transthyretin (TTR) is a plasma protein secreted by the liver that circulates bound to retinol-binding protein 4 (RBP4) and its retinol ligand. TTR is the sole plasma protein that reveals from birth to old age evolutionary patterns that are closely superimposable to those of lean body mass (LBM) and thus works as the best surrogate analyte of LBM. Any alteration in energy-to-protein bala...

PURPOSE The purpose of this study was to examine the effects of 8 weeks moderate intensity aerobic exercise on serum retinol binding protein 4 (RBP4) levels in female athletes. METHODS Twenty female karate athletics were randomly assigned to one of the exercise group (n = 10) or control group (n = 10). The training group performed endurance training 3 days a week for 8 weeks at an intensity c...

BACKGROUND The prevalence of obesity and its related comorbidities, such as fatty liver, in children is increasing worldwide mostly due to changes in diet and life-style. Many serological markers have been suggested for screening of fatty liver but investigations for finding more reliable factors are still in progress. OBJECTIVES This study aimed to investigate the correlation between the lev...

Moghadasi, M.; Nuri, R.; Ahmadi, N. Effects of 8 weeks high intensity aerobic exercise on serum retinol binding protein 4 levels in female athletes. Brazilian Journal of Biomotricity. v. 7, n. 1, p. 37-42, 2013. Retinol binding protein 4 (RBP4), has recently been identified as novel adipokines associated with obesity, type 2 diabetes and the metabolic syndrome. The effects of exercise training ...

the established risk factors for cardiometabolic disease. However, the alarming increase in overweight and obesity in children and the trajectory and reach of related comorbidities such as cardiometabolic disease challenge us to identify potential modifiable pathways that will have sufficient impact to turn these around. In this context, this study is a step in the direction of identifying uniq...