نتایج جستجو برای: rbl 2h3

تعداد نتایج: 1142  

2009
Rieko IIJIMA Parida YAMADA Junkyu HAN Hideyuki SHIGEMORI Hiroko ISODA

The immediate-type allergic reaction is involved in many allergic diseases such as asthma, allergic rhinitis, and sinusitis. The discovery of drugs for the treatment of immediate-type allergic disease is a very important subject in human health. The three kinds of phenylethanoid glycoside, acteoside, echinacoside and cistanoside A, were extracted from Cistanche tubulosa which thrives in arid la...

Journal: :Journal of cell science 2003
Elena Grimberg Ze Peng Ilan Hammel Ronit Sagi-Eisenberg

Early endosomes and a perinuclear, Rab-11-positive compartment have been implicated in the recycling of internalized receptors. In this study, we show that synaptotagmin III (Syt III), a member of the Syt family of proteins, is required for the formation and delivery of cargo to the perinuclear endocytic recycling compartment (ERC). We demonstrate that rat basophilic leukemia (RBL-2H3) mast cel...

2014
Takaaki Hiragun Yuhki Yanase Tsutomu Okabe Makiko Hiragun Mikio Kawai Michihiro Hide

Immortal mast cell lines, such as RBL-2H3 and HMC-1 cells, are commonly utilized to investigate the function of mast cells. However, they are tumor cells carrying a gain-of-function mutation of Kit. We established an immortal mast cell line without Kit mutation, NCL-2, derived from NC mouse bone marrow. NCL-2 cells could be maintained without additional growth factors and thus could respond to ...

Journal: :Journal of agricultural and food chemistry 2011
Tomoko Horiguchi Nahoko Ishiguro Kazuyasu Chihara Kazuhiro Ogi Kenji Nakashima Kiyonao Sada Naoko Hori-Tamura

The palm fruit açaí is known to have potential health benefits due to its antioxidant scavenging capacities. Pretreatment of IgE-sensitized mouse primary cultured mast cells with açaí pulp resulted in the dramatic suppression of antigen-induced degranulation in a dose-dependent manner. Similarly, açaí suppressed IgE-mediated degranulation and transcription of the cytokine genes from a cultured ...

2006
Peter Csutora Vladislav Zarayskiy Krisztina Peter Francisco Monje Tarik Smani Sergey I. Zakharov Dmitry Litvinov

Here we tested the role of calcium influx factor (CIF) and calcium-independent phospholipase A2 (iPLA2) in activation of CRAC (Ca release-activated Ca) channels and storeoperated Ca entry (SOCE) in rat basophilic leukemia (RBL-2H3) cells. We demonstrate that: 1) endogenous CIF production may be triggered by Ca release (net loss), as well as by simple buffering of free Ca within the stores; 2) s...

Journal: :Journal of immunology 2014
Vandana Singh Sandeep K Raghuwanshi Nikia Smith Elizabeth J Rivers Ricardo M Richardson

The IL-8 (CXCL8) receptors CXCR1 and CXCR2 couple to Gαi to induce leukocyte recruitment and activation at sites of inflammation. We recently showed that CXCR1 couples predominantly to the G protein-coupled receptor kinase (GRK)2, whereas CXCR2 interacts with GRK6 to regulate cellular responses. In addition to G protein-coupled receptors, GRKs displayed a more diverse protein/protein interactio...

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