Anemia is one of the most common health problems in the primary care setting. Macrocytosis in adults is defined as a red blood cell (RBC) mean corpuscular volume (MCV) >100 femtoliter (fL). Macrocytic anemias are generally classified into megaloblastic or nonmegaloblastic anemia. Megaloblastic anemia is caused by deficiency or impaired utilization of vitamin B12 and/or folate, whereas nonmegalo...

the association between helicobacter pylori (hp) infection and concentration of folate or homocysteine are still unclear. the aim of the present study was to assess the effect of  hp infection on folate and homocysteine concentrations in patients infected with hp and healthy participants. we also assessed dietary intakes of folate, vitamins b6 and b12 in two groups. in this case-control study, ...

Folate plays an important role in metabolism and its deficiency can lead to cardiovascular problems or carcinogenesis. Some studies show that narrow band UVB (NBUVB) causes folate deficiency by photolysis , while others have different opinions or even the contrary. With regard to paradoxes in this context, we decided to study the effect of NBUVB on folate levels in patients with dermatologic di...

Introduction: In recent years, bismuth-based nanomaterials have been widely used in medical researches as imaging, drug delivery and x-ray radiosensitizing agents. Due to their anti-microbial effects against Helicobacter pylori (HP), bismuth colloidal compounds are used to treat various types of diseases such as chronic gastritis. Despite their advantages, bismuth-based compoun...

Research background. Lactic acid bacteria (LAB) are known to produce folate. However, this ability is highly strain-dependent. Folate synthesis in specific LAB strains affected by the availability of folate, which can be consumed other under certain conditions. Moreover, differences folate capabilities related presence biosynthesis-related genes and regulation pathway. Experimental approach. As...

Cereals and legumes are rich in folate. However, due to the instability of folate, processing digestion can induce significant folate loss. In this paper, bioaccessibility faba bean, oat, rye wheat flours pastes was studied using a static vitro model. Folate depended on food matrices, varying from 42% 67% 40% 123% pastes. Digestion associated with interconversion formyl folates, as well increas...

background: several studies showed that elevated plasma homocysteine level is a risk factor for coronary artery disease (cad). a common polymorphism c677t of methylenetetrahydrofolate reductase (mthfr) gene is reported to be associated with decreased enzyme activity and increased blood homocysteine level. methods: this study evaluated the association between c677t polymorphism and blood homocys...

background : increased level of serum homocysteine is one of the risk factor of atherosclerosis. its production related in some sulfur amino acids such as methionine. some important cofactors that are involved in metabolic pathways of this amino acid are folate and vitamin b12. we have assessed the status of methionine, folic acid, and vitamin b12 in some coronary atherosclerotic male patients....