Rat pups deficient in n-3 fatty acids received an oral administration of docosahexaenoic acid (DHA)-rich, eicosapentaenoic acid (EPA)-free microalgal oil (DMO) or fish oil (FO). DMO administration almost restored liver EPA to the level of the control diet-fed dam's pups, but FO administration did not. This suggests that EPA could be recovered in the liver, even though EPA-free DMO was supplemen...

To study the efficacy of mannitol in reducing cerebral edema and improving the ultimate neuropathologic outcome in perinatal cerebral hypoxia-ischemia, 67 7-day postnatal rats were subjected to unilateral common carotid artery ligation followed by exposure to 8% oxygen at 37 degrees C for 3 hours. Twenty-seven rat pups received a subcutaneous injection of 0.1 ml mannitol in a dosage of 4 mg/kg ...

Effects of pre- and post-natal undernutrition on learning and memory parameters were studied in albino rats. Prenatal undernutrition was induced in rat pups by restricting the mother's diet by 50% during the entire gestation period, whereas postnatal undernutrition was induced in rat pups by restriction of their diet by rotating them between lactating and non-lactating maternalised females for ...

BACKGROUND The ability to characterize the development of metabolic function in neonatal rodents has been limited due to technological constraints. Low respiratory volumes and flows at rest pose unique problems, making it difficult to reliably measure O(2) consumption, CO(2) production, respiratory quotient (RQ), and energy expenditure (EE). Our aim was to develop and validate a commercial-grad...

OBJECTIVE The aim of the present study was to evaluate the anxiolytic properties of the new isoxazoline compounds BTG1640 and BTG1675A in comparison with diazepam. MATERIALS AND METHODS We evaluated the ultrasonic distress emission in both sexes of neonatal rat pups (which seems to be a sensitive indicator of the rat emotional reactivity and represents a valuable tool to screen compounds with...

INTRODUCTION Omega-3 fatty acid, particularly in the form of fish oil, has a structural and biological role in various systems of the body. The auditory and nervous systems are both influenced by omega-3 fatty acids, with omega-3 deficiency having devastating effects on both systems. Numerous studies have attempted to investigate this further. This study aimed to evaluate neural conduction in n...

Zayachkivsky A, Lehmkuhle MJ, Fisher JH, Ekstrand JJ, Dudek FE. Recording EEG in immature rats with a novel miniature telemetry system. J Neurophysiol 109: 900–911, 2013. First published October 31, 2012; doi:10.1152/jn.00593.2012.—Serial EEG recordings from immature rat pups are extremely difficult to obtain but important for analyzing animal models of neonatal seizures and other pediatric neu...

Background: Epilepsy is one of the most common neurological diseases globally. Mast cells are known to be the main source of brain histamine, which is identified as  being involved in seizure modulation. Sodium cromoglycate is a popular mast cell stabilizer and is proposed as the first line therapy in chronic asthma and systemic mastocytosis. Considering the importance of gestational period in ...

The consequences of chronic percutaneous gastr ic infusion of food dyes on the a c t i v i t y levels and shock avoidance performance of normal developing rats and those treated with 6-hydroxydopamine (6-OHDA) were invest igated. Al l pups were a r t i f i c i a l l y reared from four days of age and a l i qu id diet containing ei ther food dyes (D) or no colorings (N) was infused into both 6-O...

introduction: the possible effect of postnatal chemically induced hypothyroidism on nadph- diaphorase containing neurons in different cortical areas of rat neonates. materials and methods: after parturition, dams divided in two groups. the control group receiving drinking water, and experimental group receiving 0.1% ptu in their drinking water. in different postnatal days (p4, p7, p10, p15, p23...