Kalfa et al.: Genome Medicine 2009, 1:81 Abstract Granulosa cell tumors (GCTs) of the ovary belong to the group of ovarian sex-cord stromal tumors and represent 5 to 10% of ovarian malignancies. GCTs exhibit several morphological, biochemical and hormonal features of normal proliferating preovulatory granulosa cells, such as estrogen biosynthesis. Prognostic factors of this condition are lackin...

Mammalian ovarian follicular development and atresia is closely regulated by the cross talk of cell death and cell survival signals, which include endocrine hormones (gonadotropins) and intra-ovarian regulators (gonadal steroids, cytokines and growth factors). The fate of the follicle is dependent on a delicate balance in the expression and actions of factors promoting follicular cell prolifera...

Granulosa cell tumors of the ovary are malignancies that originate from the sex-cord stromal cells of the ovary and represent 2% to 5% of all ovarian cancers. Slow growth with a tendency for late recurrence characterizes a natural history of this tumor. So this tumor needs a prolonged follow-up. As a result of recent literature in Korea, the findings are 3 cases of juvenile granulosa cell tumor...

It would be desirable to expand the existing general knowledge concerning direct action of metals on the ovary. Nevertheless, the results of testing of iron compound on porcine ovarian cells should be interpreted carefully because iron is an essential element which could also induce changes in cellular processes. The aim of this in vitro study was 1) to examine dose-dependent effects of iron on...

Granulosa cells play an important part in the nutrition of the oocyte during oogenesis (Raven, 1961). Anderson & Beams (1960) suggested that, in the primary follicle, nutritive material synthesized by the granulosa cells reaches the oocyte by diffusion across the zona pellucida. In the rabbit, follicle formation and elaboration of the zona pellucida begin at the end of the second week after bir...

SUMMARY 14 15 The obtained data could expand the existing general knowledge concerning direct action of 16 metals on the ovary. Nevertheless, the results of testing of iron compound on porcine 17 ovarian cells should be interpreted carefully because iron is an essential element but on the 18 other hand it could induce changes in cellular processes. The general objective of this in 19 vitro stud...

A quantitative method is described for measuring the amount of plasminogen activator produced by rat ovarian granulosa cells following exposure to hormones in uiuo or in uitro. The results confirm the previously reported observation (Beers, W. H., Strickland, S., and Reich, E. (1975) Cell 6, (387-394) that granulosa cells in uiuo produce increasing amounts of plasminogen activator as the time o...

A quantitative method is described for measuring the amount of plasminogen activator produced by rat ovarian granulosa cells following exposure to hormones in uiuo or in uitro. The results confirm the previously reported observation (Beers, W. H., Strickland, S., and Reich, E. (1975) Cell 6, (387-394) that granulosa cells in uiuo produce increasing amounts of plasminogen activator as the time o...

Asem, Elikplimi K., Wuxuan Qin, and Stanley G. Rane. Effect of basal lamina of ovarian follicle on Tand L-type Ca21 currents in differentiated granulosa cells. Am J Physiol Endocrinol Metab 282: E184–E196, 2002.—Patch clamp experiments were conducted to study the effects of basal lamina (basement membrane) of chicken ovarian follicle on membrane Ca21 currents in differentiated chicken granulosa...