نتایج جستجو برای: rat model

تعداد نتایج: 2328568  

Journal: :Ageing and neurodegenerative diseases 2022

No single animal model can recapitulate all the features of a particular human disease on its own. Historically, rats have been used to study neurobiology and underlying functional networks. Likewise, rat models created neurodegenerative mechanisms therapeutic interventions. In last decades, shift towards use mice has observed in many research fields, not least because comparatively easier gene...

Ahmadreza Yarabi, Akram Tehranifard, Azam Moshfegh, Katayoon Dastan,

Introduction: There are many similarities between memory impairment in patients suffering from Alzheimer and animals treated by Cannabinoids. The agonists of Cannabinoid receptors affect on a variety of memories and leanings. The present study aims to investigate the role of α-1-adrenergic receptors in central region of amygdala in state-dependent learning induced by WIN55,212-2 (cannabin...

Journal: :nephro-urology monthly 0
amr ahmed el-arabey pharmacology and toxicology department, faculty of pharmacy, al-azhar university, nasr city, cairo, egypt; pharmacology and toxicology department, faculty of pharmacy, al-azhar university, nasr city, cairo, egypt. tel: +20-1006180922

Journal: :acta medica iranica 0
ali ghaffarian-bahraman department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran. and department of toxicology and pharmacology, school of pharmacy, shiraz university of medical sciences, shiraz, iran. ibrahim shahroozian department of toxicology, school of veterinary medicine, university of semnan, semnan, iran. abbas jafari department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran. and department of pharmacology and toxicology, school of pharmacy, urmia university of medical sciences, urmia, iran. mahmoud ghazi-khansari department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

the isolated perfused rat liver (iprl) model has been used into toxicology study of rat liver. this model provides an opportunity at evaluation of liver function in an isolated setting. studies showed that cd, in a dose-dependent manner, induced toxic effects in iprl models, and these effects were associated with aminotransferase activity and lipid peroxidation. the aim of this study was to inv...

Journal: :iranian journal of pharmaceutical research 0
b daraei m ghazi-khansari

t-2 toxin, a trichothecene mycotoxin, is considered to be one of the most toxic compounds that are produced by molds, particularly the fusarium species. fusarium species have been recognized as a great agricultural problem. they occur worldwide on a variety of plant hosts and cereal grains. the aim of this study was to investigate t-2 toxin-induced liver injury using in situ perfused rat liver....

Objective(s):This study aimed to establish a novel non-binding, reversible rat model of acute cholangitis of the severe type (ACST). Materials and Methods:Twenty-six rats were randomly divided into the sham-operated group (n=13) and the ACST group (n=13). All rats were intubated with a modified catheter through the external jugular vein. The ACST model was established by ligation of the distal ...

Objective(s): The present work intended to clearly define the most adequate humane endpoints in an experimental assay of mammary carcinogenesis in rats. Materials and Methods: Animals were observed twice a day; all parameters were registered once a week and the euthanasia endpoints were established in order to monitor the animal welfare/...

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شهید باهنر کرمان - دانشکده علوم پایه 1390

اسید آسکوربیک درغلظت های بالاو با انتشارپراکنده در مغز پستانداران وجود دارد . مطالعات قبلی نشان داده است که اسید آسکوربیک درسیستم عصبی مرکزی، می توانند عملکرد حافظه و یادگیری را تحت تاثیر قرار دهد. هدف از تحقیق حاضر، ارزیابی اثرات افزایشی و کاهشی اسیدآسکوربیک در داخل جسم مخطط بر روند یادگیری و حافظه فضایی در موش های صحرایی نر بالغ به وسیله ماز آبی موریس می باشد. در این تحقیق 56 سر موش صحرایی...

Hayel Shehadeh, Muhanad Akash, Wajdy Al-Awaida Wamidh H. Talib Zaid Aburubaiha,

Objective(s):One cause of cigarette smoking is oxidative stress that may alter the cellular antioxidant defense system, induce apoptosis in lung tissue, inflammation and damage in liver, lung, and kidney. It has been shown that Chinese green tea (CGT) (Lung Chen Tea) has higher antioxidant property than black tea. In this paper, we will explore the preventive effect of CGT on cigarette smoke-in...

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