نتایج جستجو برای: rat hippocampal cells
تعداد نتایج: 1615200 فیلتر نتایج به سال:
Objective . Investigate whether the disruption of normal hippocampal rhythms via optogenetic stimulation medial septum (MS) during late postnatal development has enduring effects on allocentric memory rat pups. Methods Hippocampal theta oscillations were non-endogenously regulated in pups using blue light (465-nm) pan-neuronal activation MS from day (P)21–25 random sinewave frequencies ranging ...
effects of ginkgo biloba extract on the structure of cornu ammonis in aged rat: a morphometric study
objective(s):growing evidence indicates that extract of ginkgo biloba (egb) attenuates hippocampal-dependent memory deficit in aged individuals; however, very little is known about the effect of egb on the structure of hippocampus. therefore we examined the egb-induced morphological changes of the cornu ammonis (ca) region in aged rats. materials and methods: sixteen aged male wistar rats, 24 m...
Background The pathogenesis of Alzheimer’s disease (AD) has a substantial focus on the buildup beta-amyloid plaques (Aβ) and phosphorylated Tau protein tangles, in which astrocytes are involved clearance these tangles. In addition, large prospective study type II diabetic patients that experienced hypoglycemia showed significantly higher incidence dementia. Furthermore, there was significant li...
A previous study showed that hippocampal BDNF mRNA decreased in 17 day old (D17) rats, relative to agematched naïve rats, at day 1, 3, 7 and 14 after sham surgery in a traumatic brain injury model. The anesthetic isoflurane activates GABA and inhibits NMDA receptor currents, both of which are known to decrease Brain-Derived Neurotrophic Factor (BDNF) mRNA in rat hippocampi. Hippocampal BDNF is ...
Proteome Analysis of Rat Hippocampus Following Morphine-induced Amnesia and State-dependent Learning
Morphine’s effects on learning and memory processes are well known to depend on synaptic plasticity in the hippocampus. Whereas the role of the hippocampus in morphine-induced amnesia and state-dependent learning is established, the biochemical and molecular mechanisms underlying these processes are poorly understood. The present study intended to investigate whether administration of morphine ...
We have previously shown that soluble factors derived from mesenchymal stem cells (MSCs) induce oligodendrogenic fate and differentiation in adult rat neural progenitors (NPCs) in vitro. Here, we investigated if this pro-oligodendrogenic effect is maintained after cells have been transplanted onto rat hippocampal slice cultures, a CNS-organotypic environment. We first tested whether NPCs, that ...
introduction: gap junctions are intercellular membrane channels that provide direct cytoplasmic continuity between adjacent cells. this communication can be affected by changes in expression of gap junctional subunits called connexins (cx). changes in the expression and function of connexins are associated with number of brain neurodegenerative diseases. neuroinflammation is a hallmark of vario...
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