OBJECTIVE Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterised by heterogeneous clinical manifestations, autoantibody production and epigenetic dysregulation in T cells. We sought to investigate the epigenetic contribution to the development of cutaneous manifestations in SLE. METHODS We performed genome-wide DNA methylation analyses in patients with SLE stratified...

This paper is focused on the manifestations of inter-community animosities and campanilistic rivalries in the treatise Faria - Città Vecchia e non Lesina. Pietro Hektorovich - Cittavecchiano e non Lesignano (1873) written by Hvar's scientist and historian Sime Ljubić (1822-1896). In his scientific argumentation we can find descriptions and comparisons that are more typical of creating stereotyp...

World J Pediatr, Vol 7 No 2 . May 15, 2011 . www.wjpch.com 167 Author Affiliations: Isfahan Clinical Toxicology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran (Sabzghabaee AM, Eizadi-Mood N); Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran (Nili F); Department of Pharmacognosy, Isfahan University of Medical Sciences, Isfahan, Iran (Ghannadi ...

INTRODUCTION AND OBJECTIVES Cetuximab and panitumumab are monoclonal antibodies that target the epidermal growth factor receptor (EGFR) in the treatment of metastatic colorectal cancer. Most patients develop a papulopustular rash, which may predict tumor response. We studied whether the other adverse cutaneous effects associated with these monoclonal antibodies are also clinical predictors of r...

38 Volume 25 Number 1 over the bridge of the nose along with a purplish rash over her eyelids that had been present for approximately 6 to 8 weeks. In addition, the child had a pruritic bumpy rash on her upper arms, elbows, knuckles, and knees and an elongated purplish area on her right shin. The child’s mother stated, “The facial rash seems to worsen after she has been in the sun.” The mother ...

28-year-old man came to the office with a rash on his face. He reported he has had this rash on and off for 3 years. The rash sometimes itches around his moustache, and it gets worse with stress—he has been under increasing stress for the past 2 months. He is in good health and does not have any other symptoms, and he denies any risk factors for human immunodeficiency virus (HIV). PHOTO ROUNDS ...

BACKGROUND Vandetanib is a promising anticancer target agent for treating advanced carcinomas, such as non-small-cell lung cancer (NSCLC) and breast cancer. Rash is a frequently reported adverse event of vandetanib. We conducted this meta-analysis to determine the incidence rate and overall risks of all-grade and high-grade rash with vandetanib in NSCLC patients. METHODS PubMed, Embase, Web o...

BACKGROUND A high incidence of rash has been reported in HIV-1 patients who received the anti-retroviral drug nevirapine. In addition, several studies have suggested that polymorphisms of human leukocyte antigen (HLA) genes may play important roles in nevirapine-induced rash. The aim of the present study was to evaluate the effects of different HLA-C alleles on rash associated with nevirapine i...

A 46-year-old woman presented with a facial rash that had worsened over nine months. She had been treated with several topical corticosteroids and topical antibiotics, which improved her symptoms only temporarily. She was taking no other medications. There were no specific triggers or contacts, and she had no significant medical history. Examination revealed annular plaques with a raised erythe...