which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. This 14 year-old girl presented with a 2-month history of massive increase in breast volume. She was peripubertal and became homebound ever since. On examination, she had an important bilateral and symmetric breast ptosis with widening of the nipple-areolar complex. No bre...

Near-shore waters along the northwest African margin are characterized by coastal upwelling and represent one of the world's major upwelling regions. Sea surface temperature (SST) records from Moroccan sediment cores, extending back 2500 years, reveal anomalous and unprecedented cooling during the 20th century, which is consistent with increased upwelling. Upwelling-driven SSTs also vary out of...

UNLABELLED The population ages 65 and over is expected to grow very rapidly in all parts of the world. Over the next decades, the elderly population is projected to grow much more quickly than the total population in all parts of the world. At the global level, the number of those over age 60 is projected by the UN Population Division to increase from just under 800 million in 2011 (representin...

Japanese life expectancy increased by about 13.7 years during the first decade after World War II, despite the country's post-war poverty. Although it is known that medical progress explains part of this increase, roles of non-medical factors have not been systematically studied. This study hypothesizes that non-medical factors, in addition to medical factors, are associated with the rapid incr...

The cellular content of UDP-glucose in isolated wheat (Triticum aestivum L.) embryo increases 8-fold during the first 40 minutes of imbibition. An additional 3-fold increase in the amount of UDP-glucose was observed in the next 5 hours of germination. This communication also describes a unique, quantitative method to achieve a high sensitivity in a direct determination of UDP-glucose with Na [(...

SFG rickettsiae and R. typhi have been observed, but a lack of cross-reactions has also been observed (9). It has been noted (10) that when cross-reactions were observed between R. felis and both R. conorii and R. typhi, the infection was probably related to R. felis. When cross-reactions were observed between R. felis and only R. typhi, the causative agent was most probably of the typhus group...

Acellular vaccines against Bordetella pertussis were introduced in Australia in 1997. By 2000, these vaccines had replaced whole-cell vaccines. During 2008-2012, a large outbreak of pertussis occurred. During this period, 30% (96/320) of B. pertussis isolates did not express the vaccine antigen pertactin (Prn). Multiple mechanisms of Prn inactivation were documented, including IS481 and IS1002 ...

Long-distance population dispersal leaves its characteristic signature in genomes, namely, reduced diversity and increased linkage between genetic markers. This signature enables historical patterns of range expansion to be traced. Herein, we use microsatellite loci from the human pathogen Coccidioides immitis to show that genetic diversity in this fungus is geographically partitioned throughou...

In a preceding paper of ours,1 it was reported that a relatively large amount of formiminoglutamic acid (more than O.1ƒÊ mole/ml) was excreted into urine of infants with the normal serum folate activity when an oral dose of L-histidine chloride (0.33g per kg of bodyweight) was given, and it was also suggested that this might be due to an immaturity of the formiminotransferase activity of the li...

OBJECTIVE . To monitor the implementation of in-hospital resuscitation strategies including (i) rapid defibrillation programmes, (ii) the use of amiodarone for prolonged ventricular fibrillation, and (iii) uniform data collection on resuscitation, all recommended by international guidelines published in 2000 and by Finnish national resuscitation guidelines published in 2002. DESIGN In 2004, a...