Cells within the ventral medulla whose axons descend to the spinal dorsal horn via the dorsolateral funiculus (DLF) play an important role in pain modulation. Previous evidence suggests that this pathway is primarily serotonergic. We have examined this hypothesis directly using combined retrograde horseradish peroxidase/serotonin immunohistochemical staining. Cells of the ventral medulla contri...

This is a review of research aimed at elucidating how various opiate analgesia substrates in rat brain stem interact with one another to bring about opiate analgesia. The three substrates studied are the midbrain periaqueductal grey (PAG), the bulbar nucleus raphe magnus (RM), and the bulbar nucleus reticularis paragigantocellularis (PGC). The methods used in the reviewed studies are unique in ...

Pain is an unpleasant experience which results from both physical and psychological responses to injury. A complex set of pathways transmits pain messages from the periphery to the central nervous system, where control occurs from higher centres. Primary afferent pain fibres synapse with second-order neurons in the dorsal horn of the spinal cord. Ascending spinothalamic and spinoreticular tract...

Freddy G. del Pozo, Simone Fabiano, Raphael Pfattner, Stamatis Georgakopoulos, Sergi Galindo, Xianjie Liu, Slawomir Braun, Mats Fahlman, Jaume Veciana, Concepcio Rovira, Xavier Crispin, Magnus Berggren and Marta Mas-Torrent, Single Crystal-Like Performance in Solution-Coated Thin-Film Organic Field-Effect Transistors, 2016, Advanced Functional Materials, (26), 14, 2379-2386. http://dx.doi.org/1...

Marléne Isaksson1, Annica Inerot2, Carola Lidén3,4, Magnus Lindberg5, Mihaly Matura3,4, Halvor Möller1, Berndt Stenberg6 and Magnus Bruze1 1Department of Occupational and Environmental Dermatology, Skåne University Hospital, Lund University, Malmö SE-205 02, Sweden, 2Department of Dermatology, Sahlgrenska University Hospital, Gothenburg SE-413 45, Sweden, 3 Institute of Environmental Medicine, ...

Companies’ realized earnings depend on overall economic conditions. Market participants should therfore adjust their earnings expectations to surprising macroeconomic news. However, despite its importance for asset pricing models, thus far, empirical research was not able to provide clear-cut evidence of a link between earnings expectations and economic news. Based on a detailed analysis of the...

Background: The nucleus raphe magnus (NRM) is involved in thermoregulatory processing. There is a correlation between changes in the firing rates of the cells in the NRM and the application of the peripheral thermal stimulus. Introduction: we examined the effect of reversible inactivation and excitation of NRM on mechanisms involved in tail blood flow (TBF) regulation in hypothermia. Methods: H...

In rabbits, raphe magnus/pallidus neurons form a link in the CNS pathway regulating changes in cutaneous blood flow elicited by nociceptive stimulation and activation of the central nucleus of the amygdala. To characterize relevant raphe-spinal neurons, we performed extracellular recordings from the rostral medullary raphe nuclei in anesthetized, paralyzed, mechanically ventilated rabbits. All ...