CA), and RAP (made as a recombinant fusion protein with glutathione S-transferase), as described in our original study.1 Briefly, 3 groups were tested: (1) a control group received 40 mL/kg buffer followed 15 minutes later by a second injection of 20 mL/kg buffer (n 5 11); (2) the rFVIII group received 40 mL/kg buffer followed by 200 U/kg human rFVIII in a volume of 20 mL/kg (n 5 15); (3) the R...

How do music therapists experience themselves in clinical improvisation in music therapy? The aim of this inter-disciplinary study is to show how music therapists describe and experience the life-world of the self in clinical improvisation through phenomenological investigation. Informed by sociological social psychological theory proposing that the self develops in social discourses, this stud...

Although quantifiable assessment of the singing voice is now commonplace, research on young (child and adolescent) voices is still in its infancy. There is still insufficient data on young people's voices based on which, "norms" in behavior could be modeled, particularly for contemporary commercial music (CCM), such as musical theater (MT). The objective of this study was to assess if quantifia...

Angiogenesis is an essential process for disease progression in many solid tumors. There are several major cascade events in the angiogenic process that can be targeted to inhibit new blood vessel formation in the tumor tissue. The purpose of this work is to evaluate the inhibitory effect of paclitaxel (PTX) and rapamycin (RAP) as individual and in dual drug-loaded poly(ethylene glycol)-block-p...

Dementia with Lewy bodies, Parkinson's disease, and Multiple System Atrophy are age-related neurodegenerative disorders characterized by progressive accumulation of α-synuclein (α-syn) and jointly termed synucleinopathies. Currently, no disease-modifying treatments are available for these disorders. Previous preclinical studies demonstrate that active and passive immunizations targeting α-syn p...

BACKGROUND/AIM Aldosterone (Aldo), a mediator of kidney fibrosis, is implicated in the pathogenesis of chronic kidney diseases (CKD). The aim of this study was to evaluate the regulatory role of rapamycin (Rap) in Aldo-induced tubulointerstitial inflammation and fibrosis. METHODS Uninephrectomized, Sprague-Dawley rats were given 1% NaCl (salt) to drink and were randomized to receive treatment...

this paper presents the effects of different amounts of reclaimed asphalt on fatigue life of asphalt mixtures. central composite method was used to design of experiments based on response surface method (rsm). binder type (pen 60/70 and pen 85/100), reclaimed asphalt pavement (rap) content (25, 50 and 75%) and loading strain (150, 250 and 350 micro strain) were selected as independent variables...

OBJECTIVES To investigate the influence of HLA-DRB1 alleles encoding the QK/RRAA shared epitope (SE) on radiological outcome in rheumatoid arthritis (RA), and to determine whether it is modulated by alleles carrying the putative rheumatoid arthritis-protective (RAP) sequence DERAA. Patients and methods. The association between erosive damage and HLA-DRB1 status was examined in 315 RA patients w...