Raman spectroscopy is a potent analytical tool with an extraordinary and increasing number of applications. C.V. Raman in 1928 received the Nobel Prize in Physics for this discovery which was named after him, although the technique was first predicted by A. Smekal in 1923. In the last 35 years the pace of change for this technique has been rapid, as exemplified by the number of publications in ...

With the advent of nanobiotechnology, there will be an increase in the interaction between engineered nanomaterials and biomolecules. Nanoconjugates with cells, organelles, and intracellular structures containing DNA, RNA, and proteins establish sequences of nano-bio boundaries that depend on several intricate complex biophysicochemical reactions. Given the complexity of these interactions, and...

Raman spectroscopy is a potentially important clinical tool for real-time diagnosis of disease and in situ evaluation of living tissue. The purpose of this article is to review the biological and physical basis of Raman spectroscopy of tissue, to assess the current status of the field and to explore future directions. The principles of Raman spectroscopy and the molecular level information it p...

We present the first demonstration of in vivo collection of Raman spectra of breast tissue. Raman spectroscopy, which analyzes molecular vibrations, is a promising new technique for the diagnosis of breast cancer. We have collected 31 Raman spectra from nine patients undergoing partial mastectomy procedures to show the feasibility of in vivo Raman spectroscopy for intraoperative margin assessme...

Recently, two-dimensional (2D) THz-Raman spectroscopy has been used to investigate the intermolecular modes of liquid water. We examine such 2D spectroscopy signals by means of full molecular dynamics (MD) simulations. In this way, we carry out a detailed analysis of intermolecular interactions that play an essential role in many important chemical processes. We calculate 2D Raman-THz-THz (RTT)...

The enhancement of a dissolved chemical's Raman scattering by a liquid-core optical fiber (LCOF) geometry is absorption dependent. This dependence leads to a disruption of the usual linear correlation between chemical concentration and Raman peak area. To recover the linearity, we augmented a standard LCOF Raman spectroscopy system with spectrophotometric capabilities, permitting sequential mea...

In this work a Raman flow cytometer is presented. It consists of a microfluidic device that takes advantages of the basic principles of Raman spectroscopy and flow cytometry. The microfluidic device integrates calibrated microfluidic channels- where the cells can flow one-by-one -, allowing single cell Raman analysis. The microfluidic channel integrates plasmonic nanodimers in a fluidic trappin...

In this paper functionalized multiwall carbon nanotubes (FMWCNT) were modified using doxycycline, containing reactable nitrogen, which can attach chemically to functionalized MWCNT. The synthesized nano compounds were characterized by Fourier transform infrared spectroscopy (FT-IR) and Raman spectroscopy. These spectrums proved the existence of nitrogen atoms of amide functional groups. The mor...

Graphene has been a subject of intense interest because of its unique physical properties. Raman spectroscopy became a valuable tool for determining the number of graphene layers and assessing their quality. Here we review our recent results on the effects of substrates and temperatures on Raman signatures of graphene. Specifically, we considered graphene on GaAs, glass, sapphire, standard Si/S...

Raman spectroscopy appears to be an ideal technique for the initial detection of biomarkers, molecules that are potentially indicative of life on planetary bodies elsewhere in our solar system. Carotenoids are particularly useful biomarkers as they are used widely across the species, relatively resistant to breakdown and no inorganic source is known. They are used by microorganisms in their cel...