A database of peptide chemical shifts, computed at the density functional level, has been used to develop an algorithm for prediction of 15N and 13C shifts in proteins from their structure; the method is incorporated into a program called SHIFTS (version 4.0). The database was built from the calculated chemical shift patterns of 1335 peptides whose backbone torsion angles are limited to areas o...

Original Communications Dose Response of Jejunal Sucrase and Maltase Activities to Isocaloric High and Low Carbohydrate Diets in Man. N. S. ROSENSWEIG AND R. H. HERMAN 1373 Nutritional Macrocytic Anemia of Infancy and Childhood. A. K. SARAYA, P. N. SINGLA, K. RAMACHANDRAN AND 0. P. GHAI 1378 Effect of Pyridoxine Supplementation on Glutamic-Pyruvic Transaminase and In Vitro Stimulation in Erythr...

Overuse of polymer materials has caused increasing direct human exposure to bisphenol AP (BPAP). Through the contaminated environment and food chains, adverse effects BPAP on humans plants induce growing concerns. In this study, pepsin structure changes were exhaustively investigated by multi-spectral methods. Under mimic physiological conditions, a gradient intrinsic fluorescence quenching ind...

s from the 4th European Headache and Migraine Trust International Congress: EHMTIC 2014 Copenhagen, Denmark. 18-21 September 2014 Published: 18 September 2014 These abstracts are available online at http://www.thejournalofheadacheandpain.com/supplements/15/S1 A HEADACHE TRAINEE ’S EXCELLENCE TOURNAMENTS A1 EHMTI-0117. CGRP infusion in awake rats does not increase expression of immediate early g...

Several secondary structures, such as π-helix and left-handed helix, have been frequently identified at protein ligand-binding sites. A secondary structure is considered to be constrained to a specific region of dihedral angles. However, a comprehensive analysis of the correlation between main chain dihedral angles and ligand-binding sites has not been performed. We undertook an extensive analy...

Neurological syndromes in which consciousness seems to malfunction, such as temporal lobe epilepsy, visual scotomas, Charles Bonnet syndrome, and synesthesia offer valuable clues about the normal functions of consciousness and ‘qualia’. An investigation into these syndromes reveals, we argue, that qualia are different from other brain states in that they possess three functional characteristics...