We report the synthesis by RAFT polymerization of well-defined diblock copolymers bearing carbamoylmethylphosphonate moieties which proved to sorb gadolinium. These poly(diethyl-6-(acrylamido)hexylcarbamoylmethylphosphonate-b-acrylic acid) (P(CPAAm6C-b-AA)) copolymers were able to self-assemble as a function of temperature, above their cloud point value.

Diblock copolymers possessing amino or aldehyde functions within one of their blocks were prepared using RAFT polymerization techniques. These polymers were shown to cross-link through dynamic imine bonds to form core cross-linked star polymers which display a size-dependency upon the concentration at which the cross-linking reactions are performed.

A new graft copolymer, poly(2-hydroxyethyl methacrylate-co-styrene) -graft-poly( -caprolactone), was prepared by combination of reversible addition-fragmentation chain transfer polymerization (RAFT) with coordination-insertion ringopening polymerization (ROP). The copolymerization of styrene (St) and 2-hydroxyethyl methacrylate (HEMA) was carried out at 60 °C in the presence of 2-phenylprop-2-y...

RAFT polymerization afforded acrylic ABC triblock copolymers with self-complementary nucleobase-functionalized external blocks and a low-Tg soft central block. ABC triblock copolymers self-assembled into well-defined lamellar microphase-separated morphologies for potential applications as thermoplastic elastomers. Complementary hydrogen bonding within the hard phase facilitated self-assembly an...

We introduce the fully reversible folding of single chain nanoparticles (SCNPs) based on covalent hetero Diels-Alder (HDA) chemistry. A cyclopentadiene (Cp)-protected cyanodithioester (CDTE) monomer is designed and copolymerized with methyl methacrylate (MMA) via RAFT polymerization. The polymer chains are folded and subsequently unfolded by exploiting the reversible nature of the HDA reaction.

Chemi-enzymatic synthesis of ribavirin acrylate and subsequent RAFT co-polymerization with acrylic acid afforded a formulation of a broad spectrum antiviral drug which avoids accumulation in erythrocytes, the origin of the main side effect of ribavirin. In cultured macrophages the macromolecular prodrugs exhibited decreased toxicity while maintaining the anti-inflammatory action of ribavirin.

The control over the size distribution and stability of polymeric nanoparticles (NPs) is crucial in many of their applications, especially in the biomedical field. These characteristics are typically influenced by the production method and the nature of the starting material. To investigate these aspects, the controlled radical polymerization of functionalized methacrylates constituted by 2-hyd...

In this Perspective, we discuss the recent development of polymerization-induced self-assembly mediated by reversible addition-fragmentation chain transfer (RAFT) aqueous dispersion polymerization. This approach has quickly become a powerful and versatile technique for the synthesis of a wide range of bespoke organic diblock copolymer nano-objects of controllable size, morphology, and surface f...

In this work, we synthesized end group functionalization of the cis-Norbornene-5-6-endo-dicarboxylic anhydride species via the ring-opening metathesis polymerization (ROMP) of oxanorbornene derivatives generated a chiseled poly(cis-Norbornene-5-6-endo-Dicarboxylic anhydride) acrylate macromonomer. Further, acrylate oxanorbornene based macromonomer further polymerized via reversible addition fra...

Polymerization-induced self-assembly (PISA) offers a highly versatile and efficient route to a wide range of organic nanoparticles. In this article, we demonstrate for the first time that poly(ammonium 2-sulfatoethyl methacrylate)-poly(benzyl methacrylate) [PSEM-PBzMA] diblock copolymer nanoparticles can be prepared with either a high or low PSEM stabilizer surface density using either RAFT dis...