Fusion-positive rhabdomyosarcoma (FP-RMS) is a highly aggressive childhood malignancy which mainly treated by conventional chemotherapy, surgery and radiation therapy. Since radiotherapy associated with high burden of late side effects in pediatric patients, addition radiosensitizers would be beneficial. Here, we thought to assess the role fenretinide, potential agent for FP-RMS treatment, as r...

Visible Diode Laser Enhancement of Exotic DNA Uptake by Fowl SpermEssam A. El-Gendy, Mona M. Abdelaziz, Mohamed Abdelfattah, S. Salama, YhiaM. Badr

Irinotecan (CPT-11, Camptosar) is a camptothecin derivative that is thought to exert its cytotoxic effects by targeting topoisomerase I. It is believed that irinotecan stabilizes a DNA-topoisomerase I cleavable complex, and that interactions between this complex and the replication machinery may lead to cell death. There is a significant volume of in vitro and in vivo data demonstrating that ir...