Radioactive iodine (RAI) therapy plays an important role in the management of thyroid malignancies. Leukemia is a very rare complication of radioactive therapy. There are very few case reports with doses below 100 mCi causing leukemia. We report a case of papillary carcinoma of the thyroid treated with 80 mCi RAI who later developed acute myeloid leukemia. Thus, all patients with thyroid carcin...

BACKGROUND Thyroid function in patients with Grave's disease is usually evaluated by thyroid scintigraphy with radioactive iodine. Recently, dual-energy computed tomography (DECT) with two different energy X-rays can calculate iodine concentrations and can be applied for iodine measurements in thyroid glands. This study aimed to assess the potential use of DECT for the functional assessment of ...

The soil solid-liquid distribution coefficient (Kd) value is of great significance in understanding and modelling the environmental behaviour of soil contaminants. For many years, the batch sorption technique has been used for the determination of such values. Here, we propose an alternative 'mini-column' approach in which somewhat more realistic soil conditions are maintained. In particular, t...

It is difficult to get a balanced picture of any new form of treatment, and much more difficult when new modes of diagnosis and therapy extend into the realms of atomic physics. In this article an attempt will be made to describe the present position of radioactive isotopes as applied' to surgery. Without going deeply into the physics of the subject, the author will present the principles under...

Techniques for the determination of thyroid function have become increasingly refined since the demonstration of the relation of basal oxygen consumption to thyroid activity 50 years ago. Newer methods include the determination of serum protein-bound iodine and various procedures using radioactive iodine. The latter include direct measurements of the accumulation in the thyroid gland of an admi...

Objective(s): The aim of this study was to determine whether high-dose radioactive iodine (Na131I) outpatient treatment of patients with thyroid carcinoma is a pragmatically safe approach, particularly for the safety of caregivers. Methods: A total of 79 patients completed the radiation-safety questionnaires prior to receiving high-dose radioactive iodine treatment. The questionnaire studied th...

Radioactive iodine is currently used to label proteins as a method of investigating protein metabolism in vivo or as a tracer for studies in vitro. However, recent observations indicate that changes in the molecular characteristics of proteins after iodination may lead to an apparent increase in the turnover rate in vivo (Regoeczi, 1971 ; Krohn et al., 1972). Incorporation of iodine into protei...

Recent Phase III data presented at the American Society of Clinical Oncology (ASCO) 2013 annual conference by Brose et al led to the US Food and Drug Administration (FDA) approval of sorafenib for the treatment of well-differentiated radioactive iodine-resistant metastatic thyroid cancer. This is the second drug in 40 years to be FDA approved for this indication. Recent reviews and a meta-analy...

PURPOSE To report the finding of nasolacrimal drainage system obstruction associated with radio iodine therapy and to review clinical data and the surgical treatment outcome of this rare complication. METHODS We retrospectively analyzed ophthalmological data of patients with history of thyroid carcinoma that underwent radioactive iodine I-131 therapy and were referred to lacrimal surgery. R...

OBJECTIVE To investigate the long term effect of radioactive iodine on thyroid function and size in patients with non-toxic multinodular goitre. DESIGN Consecutive patients with multinodular non-toxic goitre selected for radioactive iodine treatment and followed for a minimum of 12 months (median 48 months) after an intended dose of 3.7 MBq/g thyroid tissue corrected to a 100% uptake of iodin...